Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from an authoritative source and the process of obtaining the full study report from the data owner is on-going.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Year:
- 2 007
- Bibliographic source:
- European Chemicals Bureau; IUCLID Dataset, 4-Nitroaniline (CAS # 100-01 -6) p.49 Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of October 2, 2007
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 48
- Author:
- European Chemicals Bureau
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource);European Chemicals Bureau; IUCLID Dataset, 4-Nitroaniline (CAS # 100-01 -6) p.49 Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of October 2, 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- data obtained from Actor database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitroaniline
- EC Number:
- 202-810-1
- EC Name:
- 4-nitroaniline
- Cas Number:
- 100-01-6
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 4-nitroaniline
- Details on test material:
- - Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: not irritating to skin
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to Aggregated Computational Toxicology Resource (ACToR) database; 4-nitroaniline was not found to be irritating to the skin of rabbit.
- Executive summary:
According to Aggregated Computational Toxicology Resource (ACToR) database; 4-nitroaniline was not found to be irritating to the skin of rabbit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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