Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 201-718-9 | CAS number: 87-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Amended Safety Assessment of Sodium Polynaphthalene sulfonate and Sodium Naphthalenesulfonate
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 003
- Bibliographic source:
- International Journal of Toxicology, 22(Suppl. 2):37–44, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- A delayed contact hypersensitivity test was conducted on Guinea pigs to evaluate the skin sensitization potential of test chemical under occlusive condition.
- GLP compliance:
- not specified
- Type of study:
- other: delayed contact hypersensitivity
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- sodium naphthalene-2-sulfonate
- Cas Number:
- 532-02-5
- Molecular formula:
- C10H8O3S.Na
- IUPAC Name:
- sodium naphthalene-2-sulfonate
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): SNS (sodium 2-naphthalenesulfonate)
- Molecular formula: C10H7NaO3S
- Molecular weight: 230.23 g/mol
- Substance type: Organic
- Physical state: solid
- Smiles: c1ccc2cc(ccc2c1)S(=O)(=O)[O-].[Na+]
- InChI: 1S/C10H8O3S.Na/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10;/h1 7H,(H,11,12,13);/q;+1/p-1
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Petroleum jelly
- Concentration / amount:
- Induction exposure:
Amount : 500 mg (0.5 g)
Concentration: 30% (w/w) - Day(s)/duration:
- 3 weeks.
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Petroleum jelly
- Concentration / amount:
- Challenge exposure:
Amount : 100 mg (0.1 g)
Concentration: 30%, 10%, 3% (w/w) - Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- Total 20
control group:10
test group: 10 - Details on study design:
- RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:3
- Exposure period: 6 hour
- Test groups: Ten animals
- Control group: Ten animals
- Site: clipped and shaved Flank
- Frequency of applications: Once a week
- Duration: 3 weeks.
- Concentrations: Amount : 500 mg (0.5 g)
Concentration: 30% (w/w)
B. CHALLENGE EXPOSURE
- No. of exposures: one time
- Day(s) of challenge: after two weeks
- Exposure period: 24 h
- Test groups: Ten animals
- Control group: Ten animals
- Site: clipped and shaved Flank
- Concentrations: Amount : 100 mg (0.1 g)
Concentration: 30%, 10%, 3% (w/w)
- Evaluation (hr after challenge): 24 and 48 h
Other: Skin reactions were scored on a −, ±, +, ++, +++ scale at 24 and 48 h. - Challenge controls:
- Yes concurrent vehicle.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 30%, 10%, 3% (w/w) (100 mg)
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- In no case was there a positive response.
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Conclusions:
- None of the treated animal showed any signs of delayed contact hypersensitivity within 48 hours. Thus, the test chemical was considered to be not sensitizing in Guinea pigs.
- Executive summary:
A delayed contact hypersensitivity test was conducted on Guinea pigs to evaluate the skin sensitization potential of test chemical under occlusive condition.
Ten animals were used in the treatment group and 10 in the control group.during induction, the test site on the flank was clipped and shaved and 500mg (0.5 g) of the test chemical at a concentration of 30% (w/w) (diluted in petroleum jelly) was applied for 6 h under a closed patch, once a week, for 3 weeks. A control site received only the petroleum jelly.
Two weeks after the last application, 0.1 g each of 30%, 10%, 3%, or the petroleum jelly were applied to the shaved skin and left for 24 h under a closed patch. Skin reactions were scored on a −, ±, +, ++, +++ scale at 24 and 48 h.
None of the treated animal showed any signs of delayed contact hypersensitivity within 48 hours. Thus, the test chemical was considered to be not sensitizing in Guinea pigs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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