Bis(2,3-epoxypropyl) terephthalate

Hydrolysis

Description of key information

Determination of the Abiotic Degradation of bis(2,3-epoxypropyl)terephthalate (Hydrolysis as a Function of pH)
(GLP compliant study based on EEC directive 92/69, Annex V, Part C, Degradation, C.7, ”Hydrolysis as a Function of pH”, December 1992 and OECD Guidelines for Testing of Chemicals, Guideline No. 111, ”Hydrolysis as a Function of pH”, adopted April 13, 2004)
Authors: 	Dr. Maria Meinerling, Silke Herrmann
Study Completion Date: April 08, 2011

Key value for chemical safety assessment

Half-life for hydrolysis:

118.26 h

at the temperature of:

20 °C

Additional information

Hydrolysis of bis(2,3-epoxypropyl)terephthalate at about 10 mg a.i./L was studied in the dark at 20, 40 and 50 ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9.  The experiment was conducted in accordance with the

EEC directive 92/69, Annex V, Part C, Degradation, C.7 “Hydrolysis as a Function of pH”, December 1992 and

OECD Guidelines for Testing of Chemicals, Guideline No. 111, ”Hydrolysis as a Function of pH”, adopted April 2004

and in compliance with the GLP standards.

 The OECD Principles of Good Laboratory Practice (as revised in 1997) ENV/MC/CHEM(98)17

Chemikaliengesetz ('Chemicals Act') der Bundesrepublik Deutschland (ChemG), Anhang 1 ('Annex 1'), 2008

Directive 2004/10/EC of(Official Journal No. L 50/44).

Samples were analysed by HPLC (UV/VIS-detector). 

 

Summary: 

		reaction rate	half		Arrhenius equation
	temperature	constant	life		found
pH	[°C]	[h]	[h]
pH 4	20	0.006	118.46
pH 4	40	0.047	14.69		ln k = - 9620 * 1/T + 28
pH 4	50	0.121	5.72
pH 7	20	0.006	118.26
pH 7	40	0.047	14.61		ln k = - 10191 * 1/T + 30
pH 7	50	0.127	5.47
pH 9	20	0.037	18.92
pH 9	40	0.480	1.44		ln k = - 11870 * 1/T + 37
pH 9	50	1.641	0.42

 

This study is classified acceptable and satisfies the guideline requirement for hydrolysis study.