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EC number: 233-658-4 | CAS number: 10294-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is corrosive to skin and therefore need not be tested for acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 945 mg/m³ air
- Based on:
- other: BCl3, by transcribing the LC50 for HCl.
- Exp. duration:
- 4 h
- Remarks on result:
- other: See below for transcription procedure.
- Interpretation of results:
- other: corrosive
- Conclusions:
- BCl3 is a corrosive gas and need not be investigated for acute toxicity.
The LC50,4h is estimated to 945 mg BCl3/m³, by transcribing the LC50 for HCL, based on the degradation category approach. - Executive summary:
- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified as corrosive.
- BCl3 is classified in the CLP regulation as (Fatal if inhaled).
The LC50,4h is estimated to 945 mg BCl3/m³ (194 ppm), by transcribing the LC50 for HCL, based on the degradation category approach. This confirms the classification in Acute Tox. 2, H330.
Reference
Hydrogen chloride is a corrosive substance and will therefore dominate in the degradation category, see Section 13, the acute toxicity, compared to the other degradation product boric acid.
Known data for hydrogen chloride:
The LC50,30min values of 4701 ppm (7051mg/m3) and 5666 ppm (8500 mg/m3) have been determined for the gas and aerosol respectively, in rats and mice. The principal effects seen in acute toxicity studies were irritation of the eyes, upper respiratory tract and exposed areas of skin. When inhaled at high concentrations, the gas caused necrosis of the epithelial lining of the nasotracheal passages as well as alveolar emphysema, atelectasis and lung oedema.
7051 mg HCl/m³ is transcribed to 7557 mg BCl3/m³. Applying Haber's rule: LC50,4h = 945 mg BCl3/m³.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- the study does not need to be conducted because inhalation of the substance is likely
- Interpretation of results:
- other: corrosive
- Conclusions:
- BCl3 is classified as corrosive.
- Executive summary:
According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified as corrosive. The likely route of exposure is inhalation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified as Skin Corr. 1B, H314 on Annex VI of the CLP regulation 1272/2008.
- According to REACH, Annex XI, section 2, 'Testing is technically not possible'. Justification: BCl3 is a gas and can not be dosed orally.
- BCl3 is classified on Annex VI of the CLP regulation as Acute Tox. 2, H300.
Acute inhalation toxicity:
- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified on Annex VI of the CLP relulation 1272/2008 as Skin Corr. 1B, H314.
- BCl3 is classified on Annev VI of the CLP regulation 1272/2008 as Acute Tox. 2 *, H330 (Fatal if inhaled).
Acute dermal toxicity:
- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified on Annex VI of the CLP regulation 1272/2008 as Skin Corr. 1B, H314. The likely route of exposure is inhalation.
Justification for selection of acute toxicity – inhalation endpoint
A transcription of the LC50 of the degradation product HCl to the source substance BCl3 in the category approach is performed.
The other study by Vernot 1977 is poorly described and does not seem to be reliable.
Justification for classification or non-classification
BCl3 is classified as Acute Tox. 2, H330 (inhalation) and Acute Tox. 2, H300 (oral) according to Annex VI of the CLP regulation 1272/2008.
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