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Diss Factsheets
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EC number: 941-376-4 | CAS number: 147977-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 25 Jun - 26 Jul 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study. According to the ECHA guidance document "Practical guide 6: How to report read-across and categories (Dec 2012)", the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- THE DEPARTMENT OF HEALTH OF THE GOVERNMENT OF THE UNITED KINGDOM
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol
- EC Number:
- 272-469-1
- EC Name:
- Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol
- Cas Number:
- 68855-18-5
- IUPAC Name:
- 68855-18-5
- Details on test material:
- - Name of test material (as cited in study report): Heptanoic acid diester of neopentylglycol
- Physical state: clear colourless liquid
- Analytical purity: > 99%
- Purity test date: 2011-10-10
- Lot/batch No.: 595859
- Expiration date of the lot/batch: 2013-10-08
- Storage condition of test material: at room temperature, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: RccHanTM:WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd, Oxon, UK
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 200-350 g
- Housing: animals were housed in groups of up to 3/sex in solid-floor polypropylene cages with stainless steel lids, furnished with softwood flakes (Datesand Ltd, Cheshire, UK) and provided with environmental enrichment items (wooden chew blocks and cardboard “fun tunnels” (Datesand Ltd, Cheshire, UK)).
- Diet: Harlan 2014C Rodent Diet (Harlan Laboratories UK Ltd, Oxon, UK), ad libitum (with the exception of the exposure period)
- Water: mains drinking water, ad libitum (with the exception of the exposure period)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: cylindrical exposure chamber (ADG Developments Ltd, Hitchin, UK)
- Exposure chamber volume: 30 L
- Method of holding animals in test chamber: each rat was individually held in a tapered, polycarbonate restraining tube fitted onto a single tier of the exposure chamber and sealed by means of a rubber ‘O’ ring. Prior to the day of exposure, each rat was acclimatised for approx. 2 h to the tapered polycarbonate restraining tube.
- Source and rate of air: filtered air supplied from an oil-free compressor at 60 L/min
- System of generating particulates/aerosols: glass concentric jet nebuliser (Radleys, Saffron Walden, UK)
- Method of particle size determination: Marple Personal Cascade Impactor (Westech, IS Ltd, Beds., UK), consisting of 6 impactor stages (7.8, 5.8, 3.6, 1.4, 0.74 and 0.34 µm) with stainless steel collection substrates and a back-up glass filter, housed in an aluminium sampler
- Treatment of exhaust air: the extract from the exposure chamber passed through a ‘scrubber’ trap and was connected with a high efficiency filter to a metered exhaust system.
- Temperature, humidity, pressure in air chamber: 19-20 °C, 71-72%, negative
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetric filter analysis was used to determine the actual concentration of the aerosol. The test atmosphere was sampled at regular intervals (approx. every 10-15 min) during the exposure period. A weighed glass fibre filter was placed in a filter holder and temporarily sealed in a vacant port of the exposure chamber. A known quantity of the exposure chamber concentration was drawn through the filter using a vacuum pump. After sampling, the filter was dried in a desiccator under reduced pressure at 19-21 °C for ca. 24 h and weight thereafter.
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: see Table 1 and 2 under "Any other information on materials and methods incl. tables"
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 1.42 µm/2.56 µm
CLASS METHOD
- Rationale for the selection of the starting concentration: a target concentration of 5 mg/L was chosen based on a preliminary sighting study in two rats treated with a mean achieved test atmosphere concentration of 2.14 mg/mL. In this experiment, no significant effects were observed in the animals after an exposure period of 4 h. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric
- Duration of exposure:
- 4 h
- Concentrations:
- 5.22 mg/L (mean achieved concentration)
13.5 mg/L (nominal concentration) - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for clinical signs at hourly intervals during exposure, immediately on removal from the restraining tubes at the end of exposure, one hour after termination of exposure and subsequently once daily for over 14 days. Individual body weights were recorded on arrival, prior to treatment and on Days 1, 3, 7 and 14.
- Necropsy of survivors performed: yes, full external and internal observation. Detailed macroscopic examination of the respiratory tract was performed to determine signs of irritancy or local toxicity.
- Other examinations performed: clinical signs, body weight - Statistics:
- Mean values and standard deviations of the mean achieved atmosphere concentrations were determined.
Results and discussion
- Preliminary study:
- In a preliminary sighting study, 2 rats treated with a mean achieved test atmosphere concentration of 2.14 mg/mL (target: 2 mg/mL) showed no significant effects after an exposure period of 4 h. Clinical signs during exposure included wet fur and an increased respiratory rate. In addition, hunched posture and pilo-erection were observed directly after exposure and 1 h thereafter. The increase in respiratory rate was still present until Day 3 post-exposure. One day later, all animals were free of any clinical symptoms. No macroscopic findings were observed at necropsy. Thus, a starting concentration of 5 mg/mL was chosen for the main experiment.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.22 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: Signs of hunched posture and pilo-erection were seen in test animals for a short period after removal from the exposure chamber. Wet fur was recorded during the exposure period and for a short time period thereafter which were considered to be associated
- Body weight:
- All animals showed the expected body weight gain during the study, except for one female which did not gain weight during the 14-day observation period. In addition, one male exhibited a slight loss in body weight on the first day of exposure.
- Gross pathology:
- At necropsy, no macroscopic abnormalities were observed in the treated animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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