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EC number: 941-376-4 | CAS number: 147977-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available investigating the aquatic toxicity of Fatty acids, tall-oil, triesters with trimethylolpropane (CAS 94581-09-6). In order to fulfil the standard information requirements, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.
Ecotoxicological parameters for the aquatic toxicity of the target and the source substance are provided in the following table.
ID |
CAS |
Short term toxicity to fish |
Long term toxicity to fish |
Short term toxicity to aquatic invertebrates |
Long term toxicity to aquatic invertebrates |
Toxicity to aquatic algae |
Toxicity to microorganisms |
Target |
94581-09-6 |
RA: CAS 68002-78-8 RA: CAS 68541-50-4 RA: CAS 403507-18-6 RA: former CAS 85005-23-8 |
Data Waiving |
RA: CAS 68002-78-8 RA: CAS 68002-79-9 RA: CAS 68541-50-4 RA: CAS 403507-18-6 |
RA: CAS 68002-78-8 RA: former CAS 85005-23-8 |
RA: CAS 68002-78-8 RA: CAS 68002-79-9 RA: CAS 68541-50-4 RA: CAS 403507-18-6 |
RA: CAS 403507-18-6 RA: former CAS 85005-23-8 |
Source 1 |
68002-78-8 |
Experimental result: LL50 (96 h) >102 mg/L |
-- |
Experimental result: EL50 (48 h) >106 mg/L |
Experimental result: NOELR (21 d) ≥ 110 mg/L |
Experimental result: EL50 (72 h) >110 mg/L |
-- |
Source 2 |
68002-79-9 |
-- |
-- |
Experimental result: EC50 (48 h) >1000 mg/L |
-- |
Experimental result: EL50 (72 h) >100 mg/L |
-- |
Source 3 |
formerly 85005-23-8 |
Experimental result: LC50 (96 h) > 100 mg/L |
-- |
Experimental result: EL50 (96 h) > 100 mg/L (RL3) |
TESTING PROPOSAL |
-- |
Experimental result: EL50 (16 h) > 10000 mg/L |
Source 4 |
68541-50-4 |
Experimental result: LC50 (96 h) >48 mg/L |
-- |
Experimental result: EC50 (48 h) > 7.6 mg/L |
-- |
Experimental result: EC50 (72 h) > 3.7 mg/L |
--
|
Source 5 |
403507-18-6 |
Experimental result: LC50 (96 h) > 0.2 mg/L (nom.) |
-- |
Experimental result: EC50 (48 h) > 0.2 mg/L (nom.) |
-- |
Experimental result: EC50 (72 h) > 0.2 mg/L (nom.) |
Experimental result: EC50 (3 h) > 1000 mg/L |
The above mentioned substances are considered to be similar on the basis of the structural similar properties and/or activities. The available endpoint information on the source substances is used to predict the same endpoints forFatty acids, tall-oil, triesters with trimethylolpropane (CAS 94581-09-6). The target as well as the source substance are all characterized by the same alcohol component (trimethylolpropane) and a similar fatty acid chain lengths (C18:1 for the target substance and C18 unsatd., C18:1, C18 branched, C18 linear&branched and C16-18 (even numbered) and C18 unsat. Liner&branched for the source substances, respectively). All substances are predominantly triesters. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
All available experimental data on the source substances performed
according to internationally accepted guidelines indicate no evidence of
acute and chronic toxicity to aquatic organisms. Data for all three
trophic levels are available. No toxicity was observed up to the limit
of water solubility in all available experimental studies. The water
solubility of the target substance was determined to be 0.6 mg/L at 20
°C for the TMP esters fraction and 6.2 mg/L at 20 °C, pH6 for the total
soluble fraction, respectively. The increase in water solubility when
measuring the total soluble fraction is caused by the more soluble free
fatty acids and the mono- as well as di-esters which increase the
overall water solubility of the UVCB substance. For the read-across
substances the water solubility was measured only for the
TMP-ester-fraction. Considering this, the water solubility values of the
target and source substance are all < 1 mg/L and are thus comparable for
assessing the aquatic toxicity.
The
short-term toxicity to fish was determined in standard OECD guideline
studies from suitable read-across substances. No mortality was observed
after 96 h resulting in LC50-values > the limit of water solubility. The
same was recorded for the short-term toxicity to aquatic invertebrates
and to aquatic algae. No immobilization of Daphnia magna and no
inhibition of growth of aquatic algae were observed in experimental
studies according to OECD guidelines up to the limit of water
solubility. Due to the low water solubility, long-term testing to
aquatic invertebrates was considered to be necessary to assess the
aquatic toxicity. The available study performed with a suitable source
substance resulted in a NOELR (21 d) ≥ 0.11 g/L indicating no effects up
to the limit of water solubility. Long-term toxicity testing to fish was
not considered to be necessary since there was no evidence from the
available data that fish are more sensitive compared to aquatic
invertebrates. No toxicity to fish was observed in the available acute
tests. Thus, in order to avoid unnecessary vertebrate testing, no
long-term testing with fish was proposed.
The degradation process in commercial sewage treatment plants is not
suspected to be inhibited by the target substance. Available studies
performed with activated sludge from sewage treatment plants do not
indicate a risk since respiration of activated sludge microorganisms was
not inhibited.
Based on the result from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded thatFatty acids, tall-oil, triesters with trimethylolpropane (CAS 94581-09-6) exhibits no toxic effects on freshwater organisms up to the limit of the water solubility. As it can be seen in the data matrix of the analogue justification in IUCLID Section 13, all reliable data from the target and the source substance support the read-across by showing a consistent pattern of results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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