Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 431-060-1 | CAS number: 153719-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Summary table of ecotoxicity data of CA 2343 A:
Data in mg/l |
L(E)C-50 |
NOEC |
Fish acute |
> 100a |
|
Daphnia acute |
> 100a |
|
Algae growth inhibition |
16.4 |
3.2 |
Activated sludge |
> 100 |
|
Daphnia chron. growth |
|
56b |
aNot any adverse effects observed until 100 mg/l
bNOEC overall for Daphnia chronic toxicity tests = 56 mg/l (NOECgrowth= 56 mg/l; NOECreprotox= 120 mg/l)
Discussions on classification and labeling:
Basically the lowest L(E)C-50 from the different acute aquatic toxicity tests should be used for classification purposes. In case of CA 2343 A, the lowest EC-50 of 8.4 mg/l was obtained by the algal growth inhibition test, biomass formation. However in the same study the EC-50 for growth was determined to be 16.4 mg/l, and growth is being considered as the more significant and therefore preferable parameter. Therefore, the lowest, significant L(E)C-50 of the above shown acute aquatic toxicity tests is the result from the algal growth inhibition test (growth) of EC-50 = 16.4 mg/l. This basically implies a classification of CA 2343 as "acute aquatic toxic cat. 3" under GHS or as "N; R52" under 67/548/ECC (since 10 mg/l < EC-50 < 100 mg/l). However some differentiatons have to be observed when it comes to GHS classification within the EU (so-called CLP regulation) and GHS outside the EU (in this context named OECD-GHS).
GHS within the EU (CLP):
Acute aquatic toxicity: No classification of CA 2343, since CLP does not enforce an acute aquatic toxicity category 3.
Chronic aquatic toxicity: No classification of CA 2343, since NOEC chronic Daphnia and NOEC algal growth > 1 mg/l (note that the algal growth inhibition test acc. to OECD Guideline 201 can be accepted as aquatic chronic toxicity data, as indicated in GHS Chapter 4, Section 4.1.1.6).
OECD-GHS outside the EU (i.e. countries applying acute aquatic toxicity category 3):
Acute aquatic toxicity: CA 2343 is classified as "acute aquatic toxicity category 3", "H402 harmful to aquatic life" (since ErC-50 = 16.4 mg/l).
Chronic aquatic toxicity: No classification of CA 2343, since NOEC chronic Daphnia and NOEC algal growth > 1 mg/l (note that the algal growth inhibition test acc. to OECD Guideline 201 can be accepted as aquatic chronic toxicity data, as indicated in GHS Chapter 4, Section 4.1.1.6).
DSD - Annex VI of Directive 67/548/EEC:
Acute aquatic toxicity: CA 2343 is classified as N, "R52 harmful to aquatic organisms" (since ErC-50 = 16.4 mg/l)
Chronic aquatic toxicity: The current classification of CA 2343 acc. to Annex VI, 67/548/ECC is N; "R52/53 harmful to aquatic organisms, may cause long-term adverse effects in the environment". Basis for this classification obviously is the fact the 10 mg/l < L(E)C-50 < 100 mg/l plus the substance is not readily biodegradable. However, in Annex VI, Section 5.2.1.2, it is stated that classification for chronic aquatic toxicity R53 is not necessary as soon as aquatic long-term studies reveal NOEC > 1 mg/l, which is the case for the Daphnia chronic toxicity study and for the algal growth inhibition test acc. to OECD 201. Therefore it deems to be justified to propose no DSD classification for chronic aquatic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.