Registration Dossier
Registration Dossier
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EC number: 252-043-1 | CAS number: 34454-97-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 96-hour LC50 of C4 sulfonamido alcohol to Mysidopsis bahia was 4.4 mg/L (EPA OPPTS 850.1035, draft version at time of test). Daphnia magna was less sensitive to C4 sulfonamido alcohol toxicity. C4 glycine acid (stable biodegradation product) was not toxic to either species to a limit of 100 mg/L.
Key value for chemical safety assessment
Additional information
C4 sulfonamido alcohol underwent primary biodegradation in an inherent biodegradability test, forming C4 glycine acid as a stable product. Accordingly, toxicity to estuarine and freshwater invertebrates was assessed for both C4 sulfonamido alcohol and C4 glycine acid. The acute toxicity of C4 sulfonamido alcohol to the marine invertebrate Mysidopsis bahia was examined in a 96-hour semi-static test based on EPA OPPTS 850.1035 (then-current draft version of method), with analytical determination of concentrations. The test was based on a draft version of an accepted test guideline and was GLP compliant. It is considered reliable without restriction. In supporting studies, toxicity of C4 sulfonamido alcohol to the freshwater invertebrate Daphnia magna was assessed according to OPPTS 850.1010 and OECD 202, with analytical determination of concentrations. The 48-hour EC50 of C4 sulfonamido alcohol to Daphnia magna was 38 mg/L. In contrast, no effects by C4 glycine acid were observed in limit tests done at 100 mg/L (nominal) with either M. bahia (OPPTS 850.1035) or D. magna (OECD 202). Test soltutions were clear and colorless throughout the test, indicating that the test substance was fully soluble in the test medium. Tests of the C4 glycine acid were not GLP-compliant and were considered reliable with restrictions.
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