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Diss Factsheets
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EC number: 200-813-2 | CAS number: 74-83-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Principles of method if other than guideline:
- The test procedure followed guidelines based upon the up-and-down method described by Dixon, W.J. and Massay, F.J. in Introduction to Statistical Analysis, 3rd Ed, McGraw Hill, New York, 1969, pgs. 380-389 and Bruce, R.D. in “An Up-and-Down Procedure for Acute Toxicity Testing”, Fundam. Appl, Tox 5, 151-197, 1985.
This study differs from the prescribed method outlined in the EU Directive (EEC B2) in that the exposure time was for seven hours as opposed to the recommended 4 hours. Also, this study did not establish an LD50. - GLP compliance:
- yes
Test material
- Reference substance name:
- Bromomethane
- EC Number:
- 200-813-2
- EC Name:
- Bromomethane
- Cas Number:
- 74-83-9
- Molecular formula:
- CH3Br
- IUPAC Name:
- bromomethane
- Details on test material:
- Methyl Bromide; Batch No. SLV; Purity: 100%.
Constituent 1
Test animals
- Species:
- dog
Administration / exposure
- Details on inhalation exposure:
- The first part of this study (Part A), using an up-and-down procedure, evaluated the maximum tolerated seven-hour exposure level in dogs from a series of single, seven-hour, whole-body inhalation exposures. Physical observations were performed and body weights were measured daily.
The second part of the study (Part B), evaluated in dogs the maximum tolerated exposure level and toxicity associated with four consecutive daily seven hour exposures. Physical observations, body weights, haematology and clinical chemistry parameters were evaluated in all survivors. Animals were sacrificed, selected organs were weighed and organ/body postmortem examinations were conducted. Microscopic examinations were conducted on selected organs from the dogs utilized in part B of the study.
Results and discussion
- Preliminary study:
- In study part A, adverse clinical signs were observed after several hours of exposure, and the time of appearance was dose-related (they appeared earlier at higher doses).
In study part B, at 268 and 283 ppm Methyl Bromide, adverse clinical signs appeared on the second day of exposure. At 156 ppm, they appeared on the third day. Therefore, the toxic effect appeared cumulative. The maximum exposure level in dogs for up to 4 daily seven-hour exposures was between 55 to 156 ppm. However, because of this apparent cumulative effect, it is difficult to estimate an exposure level that the dogs would be able to tolerate during a 28 day or one year exposure.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: max. tolerable conc.
- Effect level:
- > 55 - < 156 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 d
- Remarks on result:
- other: 7 h exposure/day
- Clinical signs:
- other: Haematological evaluations indicated that HBG (haemoglobin), HCT (hematocrit), RBC (erythrocytes) and WBC (white blood cells) might have increased with Methyl Bromide exposure.
Applicant's summary and conclusion
- Conclusions:
- The maximum exposure level in dogs for up to 4 daily, seven-hour exposures was between 55 to 156 ppm.
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