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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

An overview of the studies described in 7.2.1 to 7.2.3 is given in table.
Parameter	                              Test material	                       Species	   Result	              Reference
Acute oral LD50	Methyl Bromide	Rat	104 mg/kg bw	           Kiplinger, 1994
Acute percutaneous LD50	Methyl Bromide	Rat	135mg/kg bw	           Tanaka et al, 1998
Acute inhalation LC50 (8h)	Methyl Bromide	Rat	1167 mg/L (8 h)       Honma et al, 1985

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
133 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
1 167 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
135 mg/kg bw

Additional information

Methyl Bromide is of high toxicity by the oral, dermal and inhalation routes. It is a known irritant to the eyes, skin and mucous membranes of the upper respiratory tract. Dermal exposure can cause blistering and dermatitis.

Justification for classification or non-classification

Acute oral:

The oral LD50 of liquid Methyl Bromide in rats was 104 mg/kg. The oral LD50 of microencapsulated Methyl Bromide in rats was 133mg/kg. In accordance with the provisions of Council Directive 67/548/EEC, classification as “toxic if swallowed” is required.

Acute dermal:

The dermal LD50 of Methyl Bromide in rats was found to be 135mg/kg bw. In accordance with the provisions of Council Directive 67/548/EEC, classification as “toxic in contact with skin” is required.

Acute inhalation:

A. The maximum exposure level in dogs for up to 4 daily, seven-hour exposures was between 55 to 156 ppm (equivalent to 409.66 mg/m3).

B. In rats, the LC50 value and its 95% confidence limits for an 8-hour exposure of Methyl Bromide to rats was 302 ppm (267-340) ppm (equivalent to 1.167 mg/L). In accordance with the provisions of Council Directive 67/548/EEC, classification as “toxic by inhalation” is required.