Registration Dossier
Registration Dossier
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EC number: 460-390-7 | CAS number: 26504-29-0
Endpoint summary
Administrative data
Description of key information
DIBENZYL TRITHIOCARBONATE is slightly irritating to rabbit skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The acute dermal irritation of DIBENZYL TRITHIOCARBONATE was evaluated in rabbits according to OECD 404 guideline (Ollivier, 2004b). The test item was applied undiluted to the skin of 3 New-Zealand White albino males rabbits and held in contact for 4 hours by means of a semi-occlusive dressing.
Due to the yellow coloration of the skin, the mean score over 24, 48 and 72 hours for erythema was not calculable for one animal; for both other animals, it was 1.0 and 1.3. For oedema, mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.0 and 0.0.
Under the experimental conditions, DIBENZYL TRITHIOCARBONATE was slightly irritant when applied topically to rabbits.
Eye irritation
The potential of DIBENZYL TRITHIOCARBONATE to induce ocular irritation was evaluated in rabbits according to OECD (No. 405, 24th April 2002) and EC (2004/73/EC, B.5, 29th April 2004) guidelines (Ollivier, 2004 c).
The test item was first administered to a single male New Zealand White rabbit. Since the test item was not severely irritant on this first animal, it was then evaluated simultaneously in two other animals.
A single dose of 0.1mL of the undiluted test item was instilled into the left conjunctival sac. The right eye was not treated and served as control. The eyes were not rinsed after administration of the test item.
Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration and then daily until reversibility of the ocular reactions. The mean values of the scores for chemosis, redness of the conjunctiva, iris lesions and corneal opacity were calculated for each animal.
Mean scores calculated for each animal over 24, 48 and 72 hours were 2.3, 1.0 and 1.0 for chemosis, 1.7, 1.3 and 1.3 for redness of the conjunctiva, 0.0, 0.0 and 0.0 for iris lesions and 0.0, 0.0 and 0.0 for corneal opacity.
Under these experimental conditions, DIBENZYL TRITHIOCARBONATE was slightly irritant when administered by ocular route to rabbits.
Justification for classification or non-classification
DIBENZYL TRITHIOCARBONATE was slightly irritating to the skin and eyes of rabbit, according to REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008, no classification is warranted.
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