Registration Dossier
Registration Dossier
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EC number: 460-390-7 | CAS number: 26504-29-0
Endpoint summary
Administrative data
Description of key information
The oral LD0 of DIBENZYL TRITHIOCARBONATE is higher than or equal to 2000 mg/kg in rats
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute oral toxicity of DIBENZYL TRITHIOCARBONATE was evaluated in rats according to OECD N°423 guideline (December 17th2001) (Ollivier 2004a). DIBENZYL TRITHIOCARBONATE was administered by oral route (gavage at 200 and 2000 mg/kg) to groups of 3 male and/or female fasted Sprague-Dawley rats.
No clinical signs and no mortality were observed in the animals given 200 mg/kg. At the 2000 mg/kg dose-level, no mortality occurred. No clinical signs were noted in males. In females, piloerection and dyspnea, together with hypoactivity and rhinorrea in 2/3 animals on day 1, were observed in all animals on days 1 and 2. The overall body weight gain of the animals given 200 mg/kg was not affected by treatment with the test item. The body weight gain of the males given 2000 mg/kg was slightly reduced during the first week of the study, when compared to historical control animals. The overall body weight gain of the females treated at 2000 mg/kg was similar to that of historical control animals. At necropsy, no apparent abnormalities were observed.
Under these experimental conditions, the oral LD0 of DIBENZYL TRITHIOCARBONATE in rat is higher than or equal to 2000 mg/kg in rats.
Justification for classification or non-classification
No mortality was observed at 2000 mg/kg bw by oral route, according to REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008, no classification is warranted
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