(2S)-2-amino-3-(4-{[bis(sodiooxy)phosphoryl]oxy}phenyl)propanoic acid

Auto flammability

Link to relevant study record(s)

Reference

Endpoint:

relative self-ignition temperature (solids)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2020-06-02 to 2020-06-24

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: VDI 2263, sheet 1, GrewerOven

Version / remarks:

1990

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: UN Manual of Tests and Criteria, Appendix 6 Screening Procedures, Division 4.2: Substances which may be liable to spontaneous combustion

Version / remarks:

7th edition, 2019

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Relative self-ignition temperature:

ca. 190 °C

In the investigation of self-ignition in the Grewer Oven for the pure test item first a small endothermic effect could be observed at a temperature of 140 °C which results into an exothermic effect at approx. 190 °C. This effect leads to a temperature increase up to 550 °C (corresponding temperature of the reference material 227 °C). A black residue remained in the wire basket after the test.

For the test item in mixture with Kieselguhr a weak exothermic effect could be observed starting at a temperature of approx. 180 °C which led to a temperature increase up to 310 °C (corresponding temperature of the reference material 290 °C). A grey residue remained in the wire basket after the test.

Table 1: Results of the screening lest for self-ignition in the Gewer-Oven

Experiment	Onset self- ignition / °C	Maximum temperature / °C
Pure test item	approx. 190	550
Test Item in mixture with Kieselguhr (1:1)	approx. 180	310

 

Conclusions:

The pure test item indicated a self-ignition at atmospheric pressure starting at a temperature of approx. 190 °C.

Executive summary:

A study according to UN Manual of Tests and Criteria, Devision 6.2 and VDI 2263, sheet 1 was performed to investigate the relative self-ignition of the test item. The test item was filled in a small wire basket of a volume of 8 cm³ and this wire-basket was placed into the oven. The temperature of the oven was increased with a constant heating rate (1.2 K/min) in an air stream of 100 to 120 L per hour and tho temperature of the sample was recorded as a function of time at intervals of 10 seconds. The self-ignition behavior of the pure test item was indicated as a deviation between sample temperature and reference temperature.
In the investigation of self-ignition in the Grewer Oven for the pure test item first a small endothermic effect could be observed at a temperature of 140 °C which results into an exothermic effect at approx. 190 °C. This effect leads to a temperature increase up to 550 °C (corresponding temperature of the reference material 227 °C). A black residue remained in the wire basket after the test. The relative self-ignition of the test item was determined to be at ca. 190 °C.

Description of key information

The pure test item indicated a self-ignition at atmospheric pressure starting at a temperature of approx. 190 °C (reference 4.12-1).

Key value for chemical safety assessment

Autoflammability / Self-ignition temperature at 101 325 Pa:

190 °C

Additional information

A study according to UN Manual of Tests and Criteria, Devision 6.2 and VDI 2263, sheet 1 was performed to investigate the relative self-ignition of the test item. The test item was filled in a small wire basket of a volume of 8 cm³ and this wire-basket was placed into the oven. The temperature of the oven was increased with a constant heating rate (1.2 K/min) in an air stream of 100 to 120 L per hour and the temperature of the sample was recorded as a function of time at intervals of 10 seconds. The self-ignition behavior of the pure test item was indicated as a deviation between sample temperature and reference temperature.
In the investigation of self-ignition in the Grewer Oven for the pure test item first a small endothermic effect could be observed at a temperature of 140 °C which results into an exothermic effect at approx. 190 °C. This effect leads to a temperature increase up to 550 °C (corresponding temperature of the reference material 227 °C). A black residue remained in the wire basket after the test. The relative self-ignition of the test item was determined to be at ca. 190 °C.