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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 905-459-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: Study from 1976 (no guidelines available at the time the study was performed).
- Principles of method if other than guideline:
- Draize test: 6 New Zealand Albino rabbits were dosed with 0.5 mL of undiluted TS over 24 hrs.
- GLP compliance:
- no
- Remarks:
- Study from 1976 (GLP was not compulsory at the time the study was performed).
Test material
- Reference substance name:
- Reaction mass of 1,3-diisopropylbenzene and 1,4-diisopropylbenzene
- EC Number:
- 905-459-9
- Molecular formula:
- C12H18
- IUPAC Name:
- Reaction mass of 1,3-diisopropylbenzene and 1,4-diisopropylbenzene
- Details on test material:
- Lot/batch No.: XF 958
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No further data
Test system
- Type of coverage:
- other:
- Preparation of test site:
- other: intact / abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL of undiluted TS
- Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 168 hrs
- Number of animals:
- 6
- Details on study design:
- No further data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 72 hrs average
- Score:
- 6.5
- Max. score:
- 8
- Reversibility:
- fully reversible within: 168 hrs
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 3.56
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Remarks:
- intact skin
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
Any other information on results incl. tables
Erythema (I / A) |
Oedema (I / A) |
|||||||||
Hours |
4 |
24 |
48 |
72 |
168 |
4 |
24 |
48 |
72 |
168 |
Animal No. |
||||||||||
1 |
2/2 |
3/4 |
3/4 |
3/3 |
0/0 |
2/2 |
3/4 |
2/3 |
1/2 |
0/0 |
2 |
2/2 |
4/4 |
4/4 |
4/4 |
0/0 |
2/2 |
4/4 |
3/3 |
3/3 |
0/0 |
3 |
2/2 |
4/4 |
4/4 |
4/4 |
0/0 |
2/2 |
4/4 |
3/3 |
2/2 |
0/0 |
4 |
2/2 |
4/4 |
4/4 |
3/3 |
0/0 |
2/2 |
4/4 |
3/3 |
2/2 |
0/0 |
5 |
2/2 |
4/4 |
4/4 |
3/4 |
0/0 |
2/2 |
4/4 |
3/3 |
2/3 |
0/0 |
6 |
2/2 |
3/3 |
3/3 |
3/3 |
0/0 |
2/2 |
3/3 |
2/2 |
2/2 |
0/0 |
I = intact; A = abraded
Defatting effect: skin sloughed off in 10 - 14 days. No injury in depth.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The TS was classified as severely skin irritating (24-hr exposure instead of 4-hr in the guideline).
- Executive summary:
In this older study (Draize test), 6 New Zealand Albino rabbits were dosed with 0.5 mL of undiluted TS over 24 hrs to intact or abraded skin. The irritation score (24, 72 hrs average) was given with 6.5 and the effects were fully reversible within 168 hrs. The TS was in fine not classified as skin irritating in 4h.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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