Registration Dossier
Registration Dossier
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EC number: 217-615-7 | CAS number: 1910-42-5
Neurotoxicity
Administrative data
Description of key information
As part of their re-registration review process, a recent and comprehensive evaluation by the United States EPA (EPA, 2019) assessed available studies that had used animal models to investigate the relationship between paraquat dichloride exposure and Parkinson’s Disease. The US EPA concluded that across the guideline, non-guideline, and open literature studies on paraquat, “neurotoxicity is not a common response in exposure scenarios that are anticipated to result from pesticidal use of paraquat.” They observed that “the few studies that reported PD-like effects in animal models observed those neurotoxic effects at doses at least 14 times above the current sub-chronic and chronic PoDs (points of departure), indicating that respiratory effects are a more sensitive endpoint,” and concluded that “the risk assessment accounts for and is protective of the limited evidence of neurotoxicity.”
In addition, the US EPA considered available epidemiology studies on this topic. From this literature, they concluded that “the weight of evidence was insufficient to link paraquat exposure from pesticidal uses of US registered products to PD in humans.”
EPA, 2019 (EPA-HQ-OPP-2011-0855) Systematic Review of the Literature to Evaluate the Relationship between Paraquat Dichloride Exposure and Parkinson’s Disease. https://www.regulations.gov/document/EPA-HQ-OPP-2011-0855-0125
EPA, 2019 (EPA-HQ-OPP-2011-0855) Paraquat Dichloride: Tier II Epidemiology Report. https://www.regulations.gov/document/EPA-HQ-OPP-2011-0855-0124
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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