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Diss Factsheets
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EC number: 900-600-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM-Proposed standard practice for conducting static renewal life cycle toxicity tests with daphnid, Daphnia magna (1979)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 10.6, 20.7, 41.6, 71.7, 94.4 and 137.0 mg/L
- Sampling method: concentrations were measured before and after new solutions were added, and the mean of the before and after measurements represented the concentration for a particular time interval
- Sample storage conditions before analysis: no data - Vehicle:
- no
- Details on test solutions:
- no data
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: no data
- Source: brood stock from the Environmental Research Laboratory
- Age of parental stock (mean and range, SD): no data
- Feeding during test
- Food type: mixture of finely ground trout chow and baker's yeast
- Amount: 20mg/L
- Frequency: not available
ACCLIMATION
- Acclimation conditions (same as test or not): yes
- Type and amount of food: mixture of finely ground trout chow and baker's yeast
- Feeding frequency: no data
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Remarks on exposure duration:
- periodically water renewal
- Post exposure observation period:
- no data
- Hardness:
- 44.0 mg/L (as CaCO3)
- Test temperature:
- Temperature Range: 20 °C +/- 1 °C
- pH:
- 7.1 - 7.5
- Dissolved oxygen:
- fresh solution: about 97.3 % saturation
old solution: about 73.8 % saturation - Salinity:
- 41.5 +/- 0.7 mg/L (as CaCO3)
- Nominal and measured concentrations:
- measured concentrations: 10.6, 20.7, 41.6, 71.7, 94.4, 137 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 200 mL Erlenmeyer flasks
- Type: tightly stoppered with foil wrapped neoprene stoppers
- Material, size, headspace, fill volume: 150-160 mL
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): periodically, no data
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated city water from Superior, WI, USA
no further data are available
OTHER TEST CONDITIONS
- Photoperiod: 16 h light / 8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : reproductive success and length of animals surviving exposure time.
VEHICLE CONTROL PERFORMED: no - Reference substance (positive control):
- not specified
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 41.6 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- morphology
- Details on results:
- Mean number of neonates produced by adult in the control was 164 individuals (SD: 45).
Mean length of adults in the control was 3.9 mm (SD: 0.3) - Results with reference substance (positive control):
- no data available
- Reported statistics and error estimates:
- results were analysed by one-way analysis of variance and Dunnett's procedure (p=0.05).
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the mean adult length and number of neonates per adult per reproduction day, the overall 28-day NOEC was determined to be 10.7 mg/L based on measured concentration.
- Executive summary:
The effects of 1,2 Dichloroethane on the growth and reproduction of Daphnia magna were assessed in an unaerated, static, 28-day test. Based on the mean adult length and number of neonates per adult per reproduction day, the overall 28-day NOEC was determined to be 10.7 mg/L based on measured concentration.
Reference
Description of key information
ASTM (1979) on DCE (Call, 1983):
NOEC (28d)= 10.7 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10.7 mg/L
Additional information
No experimental study was conducted on the multiconstituent substance (Flux1). Instead, a constituent-based, Weight-of-Evidence approach, was performed.
The three major constituents were targeted, representing ca 95% of a typical composition (carbon tetrachloride (CAS n° 56-23-5),1,2-Dichloroethane (CAS n°107 -06 -2) and chloroform (CAS n° 67-66 -3)). Numerous published data were available, and a single consensus value was selected for each, from a reliable source.
No average key value was derived for the multiconstituent substance: as the Risk Assessment is conducted per constituent, individual values are the key data.
The effects of 1,2 Dichloroethane on the growth and reproduction of Daphnia magna were assessed in an unaerated, static, 28 -day test (Call 1983). Based on the mean adult length and number of neonates per adult per reproduction day, the overall 28-day NOEC was determined to be 10.7 mg/L based on measured concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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