Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 900-600-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Based on a weight of evidence approach on data available on each constituents,the multiconstituent substance (Flux1) is considered as not readily biodegradable as no biodegradation of two major constituents has been observed with OECD tests (MITI Japan studies, 1992) and none of the three major constituents are expected to be biodegradable based on a QSAR (Biowin).
As a consequence, Flux1 is considered as not readily biodegradable and fulfils potential P/vP criterion in the PBT assessment.
Additional information
No experimental studies were conducted on the multiconstituent substance (Flux1). Instead, a constituent-based, Weight-of-Evidence approach, was performed.
The three major constituents were targeted, representing ca 95% of a typical composition (carbon tetrachloride (CAS n° 56-23-5),1,2-Dichloroethane (CAS n°107 -06 -2) and chloroform (CAS n° 67-66 -3)). Numerous published data were available, and a single consensus value was selected for each, from a reliable source.
No average key value was derived for the multiconstituent substance: as the Risk Assessment is conducted per constituent, individual values are the key data.
OECD readily biodegradability studies under aerobic condictions have been performed on carbon tetrachloride (CTC) and chloroform. Both studies showed no biodegradation of each constituent. These results are supported by QSAR predictions on each constituent (CTC, DCE and chloroform) where no biodegradation is expected. Even if one paper from Tabak (1981) showed a biodegradation of carbon tetrachloride and chloroform, this study is unvalidated because of the lack of details on method and control.
Based on a weight of evidence approach on data available on each constituents,the multiconstituent substance (Flux 1) is considered as not readily biodegradable as no biodegradation of two constituents has been observed with OECD tests (MITI Japan studies, 1992) and each constituent is not expected to be biodegradable (QSAR Biowin).
As a consequence, Flux1 is considered as not readily biodegradable and fulfils vP criterion of PBT assessment.
As the substance is considered as non readily biodegradable and it fullfils the "vP" criterion of the PBT asessment, the substance is considered as vP and simulation testing studies in surface water, sediment and soil do not to be conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
