Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-200-7 | CAS number: 14285-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Section 163.81 of the Regulations for the Enforcement of the Federal Insecticide, Fungicide, and Rodenticide Act (Federal Register, Wednesday, June 25, 1975).
- Principles of method if other than guideline:
- Application under a one-inch square surgical gauze patch, two layers thick, to two intact skin areas and two abraded skin areas on each of the six New Zealand White rabbits- Principle of test:
At the end of the 24-hour exposure period, the patches were removed and any residual sample was gently sponged from the skin with a moistened towel.
The reactions were scored immediately after removal of the patches (24-hour reading), and again two days later (72-hour reading), - GLP compliance:
- no
- Remarks:
- Guideline nGLP not mandatory at this date
Test material
- Reference substance name:
- Tetrahydrogen [29H,31H-phthalocyanine-2,9,16,23-tetrasulphonato(6-)-N29,N30,N31,N32]cobaltate(4-)
- EC Number:
- 238-200-7
- EC Name:
- Tetrahydrogen [29H,31H-phthalocyanine-2,9,16,23-tetrasulphonato(6-)-N29,N30,N31,N32]cobaltate(4-)
- Cas Number:
- 14285-59-7
- Molecular formula:
- C32H16CoN8O12S4
- IUPAC Name:
- tetrahydrogen [29H,31H-phthalocyanine-2,9,16,23-tetrasulphonato(6-)-N29,N30,N31,N32]cobaltate(4-)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Six New Zealand White rabbits from Plunmer's Rabbit Ranch.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: 2 abraded skin and 2 intact skin
- Vehicle:
- other: Moistened with physiological saline
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24-hour exposure
- Observation period:
- 24h and 72h
- Number of animals:
- 6
- Details on study design:
- Five-tenths gram of the undiluted test material was moistened with physiological saline and applied under a one-inch square surgical gauze patch, two layers thick, to two intact skin areas and two abraded skin areas on each of the six New Zealand White rabbits from Plunmer's Rabbit Ranch. The rabbits were acclimated to the laboratory for at least 4 days before they were dosed. The rabbits were individually identified by means of numbered ear tags. The application sites were prepared by clipping the hair from the saddle area of the rabbits. The abraded areas were prepared by making minor epidermal incisions with a hypodermic needle. The abrasions were sufficiently deep to penetrate the epidermis, but not to induce bleeding. Each patch was held in place with two strips of one-inch adhesive tape. After application of the patches, the trunk of each rabbit was
wrapped with rubber dental damming, which was secured with staples. An outer layer of gauze and tape was placed around the trunk of each animal. The animals were restrained in Newmann harnesses for 24 hours.
At the end of the 24-hour exposure period, the patches were removed and any residual sample was gently sponged from the skin with a moistened towel.
The reactions were scored immediately after removal of the patches (24-hour reading), and again two days later (72-hour reading), according to the scale reproduced in Table 4 accompanying this report.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- For intact skin
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 0.5
- Reversibility:
- not specified
- Remarks on result:
- other: 48h not assessed
- Remarks:
- 48h not assessed, scoring at 48 hours not performed
- Irritation parameter:
- edema score
- Remarks:
- For intact skin
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.04
- Max. score:
- 0.25
- Reversibility:
- not specified
- Remarks on result:
- other: 48h not assessed
- Remarks:
- 48h not assessed, scoring at 48 hours not performed
- Irritant / corrosive response data:
- Irritative effects noted at the 24-hour reading included very slight erythema at three intact and five abraded sites. Very slight edema was noted at one intact site and two abraded sites at the 24-hour reading.
Irritative effects noted at the 72-hour reading were limited to very slight erythema at one intact site.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Following a 24-hour patch application of Cobalt Phthalocyanine Tetrasulfonate to the intact and abraded skin areas on the back of New Zealand White rabbits, the Primary Irritation Index was found to be 0.25.
Under tests conditions, results are considered scientifically valid to support a non classification according to GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.