Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 601-499-3 | CAS number: 117933-89-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- The sample was sent to Centre for Toxicology and Development Research (CEFT), Sri Ramachandra medical Centre, Chennai-600116, India
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 44 Days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane
- EC Number:
- 601-499-3
- Cas Number:
- 117933-89-8
- Molecular formula:
- C17H30O2
- IUPAC Name:
- 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male
Results and discussion
In vivo (LLNA)
Results
- Key result
- Parameter:
- other: Not specified in the study report
- Remarks on result:
- other: As per OECD 406, its Weak Sensitizer, Grade 1
Applicant's summary and conclusion
- Interpretation of results:
- other: As per OECD 406, it is a weak sensitizer,Grade 1
- Conclusions:
- 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane is a ''Weak Sensitizer, Grade 1" as classified according to OECD harmonised classification System during the test period.
The method followed for the classiication is " Magnusson and Kligman" rating of Allergenicity.
The complete study was performed in compliance with OECD guidelines number 406.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
