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EC number: 948-020-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1983
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-(octyldisulfanyl)octane; 2-(octyldisulfanyl)-5-[(octylsulfanyl)disulfanyl]-1,3,4-thiadiazole; 2-(octyldisulfanyl)-5-{[5-(octyldisulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-1,3,4-thiadiazole; bis(octyldisulfanyl)-1,3,4-thiadiazole
- EC Number:
- 948-020-7
- Molecular formula:
- N/A
- IUPAC Name:
- 1-(octyldisulfanyl)octane; 2-(octyldisulfanyl)-5-[(octylsulfanyl)disulfanyl]-1,3,4-thiadiazole; 2-(octyldisulfanyl)-5-{[5-(octyldisulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-1,3,4-thiadiazole; bis(octyldisulfanyl)-1,3,4-thiadiazole
- Test material form:
- liquid
- Details on test material:
- EC Number: 948-020-7
Constituent 1
- Specific details on test material used for the study:
- Sponsor Test Article ID : OD-826, Lot #DU71/2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New England White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Externally sourced
- Sex: Female
- Weight at study initiation: Ranged from 2.36 to 2.78 Kg
- Housing: All housing and care conformed to the standards established in "Guide for the Care and Use of Laboratory Animals" DHEW Publication No. (NIH) 78-23. The rabbits were individually housed in wire mesh bottom cages in an environment controlled room.
- Diet: NIH Animal Feed A (certified), ad libitum
- Water: as libitum
- Acclimation period: A minimum of 5 days
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.1 ml of the test substance
- Duration of treatment / exposure:
- 1 dose / 14 days exposure
- Observation period (in vivo):
- 1, 24, 48 and 72 hours. Readings were made every 3 day thereafter, if injury persisted, for at least 13 days after treatment.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not specified
SCORING SYSTEM:
- Draize Scale
TOOL USED TO ASSESS SCORE:
- Sodium fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Draize Scale
- Remarks:
- Mean Eye Irritation Scores
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 6
- Reversibility:
- not specified
- Irritation parameter:
- other: Draize Scale
- Remarks:
- Mean Eye Irritation Scores
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.7
- Reversibility:
- not specified
- Irritation parameter:
- other: Draize Scale
- Remarks:
- Mean Eye Irritation Scores
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.3
- Reversibility:
- not specified
- Irritation parameter:
- other: Draize Scale
- Remarks:
- Mean Eye Irritation Scores
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
Any other information on results incl. tables
The treated eyes were examined with the aid of sodium fluorescein and the grade of ocular reaction was recorded for all animals at l, 24, 48 and 72 hours using the Draize Scale for Scoring Ocular Lesions. Readings were made every 3 day thereafter, if injury persisted, for at least 13 days after treatment or until all signs of reversible toxicity subsided. The mean eye irritation scores were 6.0, 0.7, 0.3 and 0 at l, 24, 48 and 72 hours, respectively. The test substance was considered to be moderately irritating to the eye of rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study, the test substance was considered to be moderately irritating to the eye of rabbits. The results indicate no means scores above 1 after 24 hours and fully reversed by 72 hours.
- Executive summary:
To determine the potential of the test material to cause irritation to the eye a study was conducted in accordance to OECD guidelines under GLP conditions. The study has been given a Klimisch score of 1 and is considered to be a key study. Six female New England White rabbits were treated with 0.1 mL test material in one eye and the other eye remained untreated and this was used as a control. The treated eyes were examined with the aid of sodium fluorescein and the grade of ocular reaction was recorded for all animals at 1, 24, 48 and 72 hours using the Draize Scale for Scoring Ocular Lesions. Readings were made every 3 day thereafter, if injury persisted, for at least 13 days after treatment or until all signs of reversible toxicity subsided. The mean eye irritation scores were 6.0, 0.7, 0.3 and 0 at 1, 24, 48 and 72 hours, respectively. The test substance was considered to be moderately irritating to the eye of rabbits.
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