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EC number: 948-020-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 August 1983 to 26 September 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-(octyldisulfanyl)octane; 2-(octyldisulfanyl)-5-[(octylsulfanyl)disulfanyl]-1,3,4-thiadiazole; 2-(octyldisulfanyl)-5-{[5-(octyldisulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-1,3,4-thiadiazole; bis(octyldisulfanyl)-1,3,4-thiadiazole
- EC Number:
- 948-020-7
- Molecular formula:
- N/A
- IUPAC Name:
- 1-(octyldisulfanyl)octane; 2-(octyldisulfanyl)-5-[(octylsulfanyl)disulfanyl]-1,3,4-thiadiazole; 2-(octyldisulfanyl)-5-{[5-(octyldisulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-1,3,4-thiadiazole; bis(octyldisulfanyl)-1,3,4-thiadiazole
- Test material form:
- liquid
- Details on test material:
- EC Number: 948-020-7
Constituent 1
- Specific details on test material used for the study:
- Sponsor ID: OD-826
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Animals and Animal Husbandry: All housing and care conformed to the standards established in "Guide for the Care and Use of Laboratory Animals" DHEW publication No. (NIH) 78-23.
- Species/Strain: Sprague-Dawley Rats
- Source: External
- Age at Initiation: Young adult
- Number/Sex: 5/sex/dosage level
- Housing: Individually housed in wire mesh bottom cages
- Food: ad libitum, (except during the exposure period); supplied fresh each week
- Water: Tap water, ad libitum, except during the exposure period
- Environment: All animals housed in environment controlled rooms with temperature and
relative humidity regulated as per "Guide for the Care and Use of Laboratory Animals". Filtered air supplied provided 12 - 15 air changes per hour. A 12 hour light-dark cycle was maintained.
- Quarantine: Minimum of 5 days
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Aerosol Generation and Exposure
Each group was exposed (wholebody) for 262 minutes in a 309 L stainless steel and glass. Twenty- two minutes were added to the 240 minute exposure period in order to allow the test atmosphere to reach its equilibrium concentration.
The test article was atomized by means of one or two ball jet nebulizers. The aerosol was mixed and diluted with ambient air as it entered the chamber. Total airflow through the chamber was maintained at a rate of 65 L/minute using a transvector jet mounted to the chamber exhaust.
Airflow through the system was monitored using a pre-standardized pressure gauge attached to the transvector jet. The test atmosphere was vented via an air treatment system consisting of a glass fiber prefilter, Micretain® HEPA filter and an activated charcoal bank.
The animals remained in the chamber for at least 25 minutes following exposure. The system was operated at the designated flow rate using ambient air only during this period. - Duration of exposure:
- 4 h
- Concentrations:
- 0, 0.30, 1.68, 2.48, 3.17, or 3.28 mg/L
- No. of animals per sex per dose:
- 5 per sex per dose
- Details on study design:
- Morbidity, mortality, and clinical signs were recorded twice daily for 14 days. Body weights were recorded on days 1, 4, 8, and 15.
Actual chamber aerosol concentration was determined twice each hour by gravimetric analyses.
Particle size analyses were performed twice per hour for all groups using a multijet cascade impactor.
Greater than 97% of the particles were less than or equal to 10 µm in size. Gross necropsies were performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3.08 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: lower and upper 95% confidence intervals of 2.78 mg/L and 3.50 mg/L, respectively
- Other findings:
- Decreased activity was noted during the first 3 days in rats of 2.48, 3.17, and 3.28 mg/L groups as activity levels of surviving animals returned to normal by Study Day 4. Laboured breathing was observed among all surviving animals at 2.48 mg/L and in one male at 3.17 mg/L. Respiratory rates returned to normal during the first week. Decreased body weight gain was noted during the first week in males of treated groups but was comparable at Study Day 15. Transient weight loss occurred during the first week in the surviving female exposed to 3.28 mg/L. No treatment related lesions or abnormalities were noted at necropsy of surviving animals. However, pulmonary erythema (reddened lungs) was present in animals found dead in the 3.17 and 3.28 mg/L dose groups. Moderate oedema (fluid present in the lungs) was noted among animals found dead in the 3.28 mg/L dose group. The mortality occurred during the first 2 days, 1/5 male, 4/10 (3 males and 1 female), and 8/10 (4/sex) animals were found dead in the 2.48, 3.17, and 3.28 mg/L dose groups, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of the study, the sex combined LC50 was 3.08 mg/L with lower and upper 95% confidence intervals of 2.78 mg/L and 3.50 mg/L.
- Executive summary:
A study has been performed to determine the acute inhalation toxicity of the test material. The study has been conducted under GLP conditions and to OECD guidelines. The study has been given a Klimisch Score of 1. Test substance batch number is included in the study report, but test substance characterization is not included in the study report. Sprague-Dawley rats, 5 per sex per dose were used in this study. The animals were with dosed liquid droplet aerosol containing 0, 0.30, l.68, 2.48, 3.17, or 3.28 mg/L test substance for 4 hours via the inhalation route utilizing whole body exposure. Morbidity, mortality, and clinical signs were recorded twice daily for 14 days. Body weights were recorded on days 1, 4, 8, and 15. Actual chamber aerosol concentration was determined twice each hour by gravimetric analyses. Particle size analyses were performed twice per hour for all groups using a multijet cascade impactor. Greater than 97% of the particles were less than or equal to 10 µm in size. Gross necropsies were performed. Decreased activity was noted during the first 3 days in rats of 2.48, 3.17, and 3.28 mg/L groups as activity levels of surviving animals returned to normal by Study Day 4. Laboured breathing was observed among all surviving animals at 2.48 mg/L and in one male at 3.17 mg/L. Respiratory rates returned to normal during the first week. Decreased body weight gain was noted during the first week in males of treated groups but was comparable at Study Day 15. Transient weight loss occurred during the first week in the surviving female exposed to 3.28 mg/L. No treatment related lesions or abnormalities were noted at necropsy of surviving animals. However, pulmonary erythema (reddened lungs) was present in animals found dead in the 3.17 and 3.28 mg/L dose groups. Moderate oedema (fluid present in the lungs) was noted among animals found dead in the 3.28 mg/L dose group. The mortality occurred during the first 2 days, 1/5 male, 4/10 (3 males and 1 female), and 8/10 (4/sex) animals were found dead in the 2.48, 3.17, and 3.28 mg/L dose groups, respectively. The sex combined LC50was 3.08 mg/L with lower and upper 95% confidence intervals of 2.78 mg/L and 3.50 mg/L.
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