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EC number: 221-359-1 | CAS number: 3077-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Necropsy was not performed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 1987
- Deviations:
- yes
- Remarks:
- Necropsy was not performed.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-[(4-methylphenyl)imino]bisethanol
- EC Number:
- 221-359-1
- EC Name:
- 2,2'-[(4-methylphenyl)imino]bisethanol
- Cas Number:
- 3077-12-1
- Molecular formula:
- C11H17NO2
- IUPAC Name:
- 2,2'-[(4-methylphenyl)imino]diethanol
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Wistar TNO W 74
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: 9 weeks (males); 14 weeks (females)
- Weight at study initiation: 166 - 189 g (males); 168 - 192 g (females)
- Housing: 5 animals/group were housed in macrolon typ III cages with wood granulat as bedding material
- Diet: Altromin R 1324 (Altromin GmbH, Lage, Germany), ad libitum
- Water: Tap water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1.5
- Humidity (%): 60 ± 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSAGE PREPARATION:
The test substance was slightly heated prior to administration. - Doses:
- 0.1, 0.5, 1.0, 1.5, 2.0 and 2.5 mL/kg bw (equivalent to 109, 545, 1090, 1635, 2180 and 2725 mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for signs of toxicity and mortality several times on the day of administration, twice daily thereafter and once daily on weekends and public holidays. The body weight was recorded prior to the administration and thereafter once weekly.
- Necropsy of survivors performed: no - Statistics:
- Probit analysis was used for the calculation of the LD50 value.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.88 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Probit analysis
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 959 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: by calculation using a density of 1.09 g/cm³
- Mortality:
- 109 mg/kg bw: no mortality occurred.
545 mg/kg bw: 2/5 males and 1/5 females died 1 h post-administration.
1090 mg/kg bw: 3/5 males and 2/5 females died 1 h post-administration.
1635 mg/kg bw: 4/5 males and 3/5 females died 1 h post-administration.
2180 mg/kg bw: 5/5 males and 3/5 females died 1 day post-administration.
2725 mg/kg bw: 3/5 males died on Day 2 and 2/5 males died on Day 3 after administration of the test substance, respectively. All females died on Day 1 after administration of the test substance. - Clinical signs:
- other: 109 mg/kg bw: no clinical signs occured in all animals. 545 mg/kg bw: tremor, convulsions and a decline in general conditions were observed in all males and females 10 min after administration of the test substance. These effects persisted in 3/5 males up
- Gross pathology:
- Necropsy was not performed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS Category 4, H302 according to Regulation (EC) No. 1272/2008.
- Conclusions:
- In an acute oral toxicity study with rats, performed similar to OECD 401, a LD50 of 959 mg/kg bw was determined.
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