Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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Reaction products of disodium hydroxysubstitutedpolycycledisulphonate reacted with 2,4,6-trichloro-1,3,5-triazine, subsequently coupled with diazotized 2-[(p-substitutedphenyl)sulphonyl]ethyl hydrogen sulphate, subsequently reacted with disodium hydroxysubstitutedpolycycledisulphonate and subsequently coupled with diazotized disodium substitutedpolycycledisulphonate
EC number: - | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- Version / remarks:
- February, 04th, 2015
- Principles of method if other than guideline:
- The test item absorbs in the same wavelength as the MTT range. In order to assess a possible interference, control on the test item range of dilution was carried out under the same conditions as the test but the MTT was not added to the culture well.
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- activation of keratinocytes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: particulate/powder
In vitro test system
- Details on the study design:
- The test consists in evaluating the activation of AKR1C2 in transformed keratinocytes (KeratinoSens™), by monitoring the induction of the luciferase gene fused to AKR1C2. The luciferase produced by the cells complexes with luciferin which, in the presence of ATP, produces light measured in relative light units (RLU).
Results and discussion
In vitro / in chemico
Results
- Key result
- Run / experiment:
- other: two
- Parameter:
- other: Induction
- Remarks:
- of luciferase activity
- Value:
- 0.79
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the retained experimental conditions RED STR 172 code ID-18/07953 may be classified as not sensitizer.
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