Registration Dossier
Registration Dossier
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EC number: 205-305-4 | CAS number: 137-66-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- 10 mice per dose were treated once by oral gavage and observed for 10 days for time of death
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6-O-palmitoylascorbic acid
- EC Number:
- 205-305-4
- EC Name:
- 6-O-palmitoylascorbic acid
- Cas Number:
- 137-66-6
- Molecular formula:
- C22H38O7
- IUPAC Name:
- 6-O-palmitoylascorbic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After one oral application of ascorbyl palmitate in mice, the LD50 was clearly above 2000 mg/kg bw (LD50 > 20'000 mg/kg bw). Therefore, the GHS criteria for classification are not met.
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