3,3-dimethylbutanone

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

1

Reference substance name:

3,3-dimethylbutanone

EC Number:

200-920-4

EC Name:

3,3-dimethylbutanone

Cas Number:

75-97-8

Molecular formula:

C6H12O

IUPAC Name:

3,3-dimethylbutanone

Test material form:

liquid

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

yes

Remarks:

test medium

Details on test solutions:

test concentrations : 55, 100, 180, 324, 583 and 1050 mg/l

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

other: test medium

Limit test:

no

Total exposure duration:

48 h

Test conditions

Hardness:

270

Test temperature:

22°C

pH:

7.9

Dissolved oxygen:

9.1

Nominal and measured concentrations:

Nominal : 55, 100, 180, 324, 583 and 1050 mg/L

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 323.6 - < 478.6 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Key result

Duration:

24 h

Dose descriptor:

EC50

Remarks:

Mean

Effect conc.:

390.5 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 3

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 273.6 - < 402.8 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 4

Key result

Duration:

48 h

Dose descriptor:

EC50

Remarks:

Mean

Effect conc.:

329.9 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Results with reference substance (positive control):

The unknown standards and the quality controls are well within 42.5 mg/L and 57.5 mg/L.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The toxicity to aquatic invertebrates was determined according to OECD 202 guideline on Daphnia magna. Th study shows that the test item pinacolone give :
- EC50 - 24h = 390.5 mg/L
- EC50 - 48h = 329.9 mg/L
The test item is not considered to be toxic for aquatic invertebrates after short-term exposure.

Executive summary:

The toxicity to aquatic invertebrates was determined according to OECD 202 guideline on Daphnia magna. Th study shows that the test item pinacolone give :

- EC50 - 24h = 390.5 mg/L

- EC50 - 48h = 329.9 mg/L

The test item is not considered to be toxic for aquatic invertebrates after short-term exposure.