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EC number: 243-175-0 | CAS number: 19592-55-3
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 Jan 2013 - 05 Feb 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: In accordance with GLP and well characterised substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320:2009 and CIPAC MT 187
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Principles of method if other than guideline:
- laser diffraction
- GLP compliance:
- yes
- Remarks:
- 2004/10/EC plus OECD
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- 3,20-bis(ethylenedioxy)pregna-5,7-diene
- EC Number:
- 243-175-0
- EC Name:
- 3,20-bis(ethylenedioxy)pregna-5,7-diene
- Cas Number:
- 19592-55-3
- Molecular formula:
- C25H36O4
- IUPAC Name:
- (1S,3aR,9aR,9bS,11aS)-9a,11a-dimethyl-1-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,3a,6,8,9,9a,9b,10,11,11a-dodecahydrospiro[cyclopenta[a]phenanthrene-7,2'-[1,3]dioxolane]
- Test material form:
- solid: crystalline
- Details on test material:
- Slightly yellow powder.
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 247.4 µm
- Geometric standard deviation:
- >= 0.03 - <= 0.78
Particle sizeopen allclose all
- Percentile:
- D10
- Mean:
- 30.581 µm
- St. dev.:
- 0.22
- Percentile:
- D50
- Mean:
- 222.975 µm
- St. dev.:
- 2.38
- Percentile:
- D90
- Mean:
- 874.227 µm
- St. dev.:
- 5.16
- Percentile:
- other: d15.78
- Mean:
- 55.921 µm
- St. dev.:
- 0.42
- Percentile:
- other: volume of sample < 10 um
- Mean:
- 3.09 other: %
- Remarks on result:
- other: volume of sample <10um
Any other information on results incl. tables
RUN1 RUN2 RUN3 RUN4 RUN5 **Average
Volume weighted Mean 354.480 355.505 354.993 352.557 352.319 353.971
Median (d.50) 216.424 219.607 222.757 220.209 222.975 220.402
Mode(µm) 197.766 194.750 243.259 259.700 273.065 233.705
*MMAD 242.935 246.508 250.044 247.184 250.289 247.400
10% of material is < 30.105 30.602 30.688 30.294 30.581 30.453
50% of material is < 216.424 219.607 222.757 220.209 222.975 220.402
90% of material is < 891.344 884.275 878.816 878.768 874.227 881.492
All results are in µm
*Mass Median Aerodynamic Diameter
**Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
3.09% by volume of sample was seen to be < 10.00µm
Applicant's summary and conclusion
- Conclusions:
- The test substance MMAD (Mass Median Aerodynamic Diameter) was reported at 247.400 um and 3.09% of volume of sample is less than < 10 um.
- Executive summary:
Summary of results
Particle Size Analysis using small volume (wet) module (SVM). Average (µm)
Volume weighted mean 353.971
Median (d.50) 220.402
Mode 233.705
MMAD (Mass Median Aerodynamic Diameter) 247.400
10% of material is < (d10) 30.453
50% of material is < (d50) 220.402
90% of material is < (d90) 881.492
volume of sample.< 10.00 µm 3.09 %
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