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EC number: 225-207-5 | CAS number: 4717-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-02-01 to 2010-02-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Daphnia sp., Acute Immobilization test stipulated in the "Testing Methods for New Chemical Substances" of Japan
- Version / remarks:
- 2006
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Samples of all concentrations were taken at the start and at the end of exposure.
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Clone A
- Source: The University of Sheffield (Address: Sheffield SlO 2UQ, United Kingdom)
- Age of parental stock (mean and range, SD): > 14 days
- Feeding during test: No.
ACCLIMATION
- Acclimation conditions (same as test or not): Yes.
- Type and amount of food: Chlorella vulgaris: 0.1 - 0.2mg organic carbon content/day_daphnia - Test type:
- static
- Water media type:
- freshwater
- Remarks:
- dechlorinated tap water
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20.2 - 20.3°C
- pH:
- 7.7
- Dissolved oxygen:
- 8.5 - 8.8 mg/L
- Nominal and measured concentrations:
- nominal: 0 (control) and 100 mg/L
measured: 0 (control) and 98 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Petri dish (diameter 8.0 cm x depth 5.0 cm), filled with approx. 250 mL test solution
- Type: Closed with glass plate
- Aeration: No
- Renewal rate of test solution (frequency/flow rate): No
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water
- Total organic carbon: 0.1 mg/L
- Particulate matter: < 1 mg/L
- Metals: Yes, all concentration < 0.0005 mg/L
- Chlorine: 14 mg/L
- Alkalinity: 35 mg/L
- Ca/Mg ratio: 3.46
- Culture medium different from test medium: No.
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16-hour light/8-hour dark
- Light intensity: Not stated
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Immobility of daphnids after 24 and 48 hours.
RANGE-FINDING STUDY
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: Yes. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 98 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: No.
- Results with reference substance (positive control):
- The EC50-value of the daphnia acute toxicity test with potassium chromate was within the stipulated range (mean ± 2S.D.: 0.13 - 0.36 mg/L) to background data in the laboratory [mean ± S.D.: 0.24 ± 0.056 mg/L (n=69)].
- Validity criteria fulfilled:
- yes
- Conclusions:
- As no immobility was observed in the highest test concentration, the 48-hour EC50 was determined as > 100 mg/L based on nominal concentration.
- Executive summary:
The toxicity of the test item Tetrahydro-4-methyl-2H-pyran was examined in a acute daphnia test according to OECD 202 and under GLP conditions. Individuals of D. magna were exposed to 0 (control) and 100 mg/L of the test substance, equivalent to 98 mg/L mean measured concentration, for 48 hours. Concentrations were analytically verified via GC-FID. As no immobility was observed in the highest test concentration, the 48-hour EC50 was determined as > 100 mg/L based on nominal concentration.
Reference
Table 1: Immobility of daphnids
Nominal concentration(mg/L) |
Immobility % |
||||
|
|
24 hours |
48 hours |
||
|
Replicates |
Test level |
Replicates |
Test level |
|
Control |
A |
0 |
0 |
0 |
0 |
|
B |
0 |
0 |
0 |
0 |
|
C |
0 |
0 |
0 |
0 |
|
D |
0 |
0 |
0 |
0 |
100 |
A |
0 |
0 |
0 |
0 |
|
B |
0 |
0 |
0 |
0 |
|
C |
0 |
0 |
0 |
0 |
|
D |
0 |
0 |
0 |
0 |
Table 2: Conditions of the test
Nominal concentration(mg/L) |
Dissolvedoxygen concentration(mg/L) |
pH |
Temperature(°C) |
|||||
|
Start |
End |
Start |
End |
Start |
End |
||
Control |
8.8 |
8.5 |
7.7 |
7.7 |
20.3 |
20.2 |
||
100 |
8.8 |
8.5 |
7.7 |
7.7 |
20.3 |
20.2 |
Description of key information
EC50 (48-h) > 100 mg/L based on nominal concentration
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The toxicity of the test item Tetrahydro-4-methyl-2H-pyran was examined in a acute daphnia test according to OECD 202 and under GLP conditions. Individuals of D. magna were exposed to 0 (control) and 100 mg/L of the test substance, equivalent to 98 mg/L mean measured concentration, for 48 hours. Concentrations were analytically verified via GC-FID. As no immobility was observed in the highest test concentration, the 48-hour EC50 was determined as > 100 mg/L based on nominal concentration.
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