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EC number: 225-207-5 | CAS number: 4717-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-08-06 to 2009-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: "Method for Testing the Biodegradability of Chemical Substances by Microorganisms" stipulated in the "Testing Methods for New Chemical Substances"
- Version / remarks:
- 2006
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): collected, prepared and controlled by Chemicals Evaluation and Research Institute
- Storage conditions: activated sludge was cultivated for 18.5h after the synthetic sewage has been added
- Concentration of sludge: 30 mg/L (as concentration of suspended solid) - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The basal culture medium was prepared based on the following method: purified water was added to each 3 mL aliquot of solutions A, B, C and D, which are described in (JIS) K 0102-2008 Section 21, in order to prepare the solution. The pH of this solution was then adjusted to 7.0.
- Test temperature: 25±1°C
- pH adjusted: Yes (culture medium)
- Continuous darkness: Yes
TEST SYSTEM
- Culturing apparatus: Vessels filled with 300 mL
- Number of culture flasks/concentration: One vessel for test item and water, 3 vessels for test item and sludge, 1 vessel with aniline and sludge (reference control), 1 vessel with medium and sludge (control blank).
- Aeration of dilution water: By using a magnetic stirrer.
- Measuring equipment: Asahi Techneion Co., Ltd.
- Test performed in closed vessels due to significant volatility of test substance: Yes
SAMPLING
- Sampling frequency: at the end of the incubation
- Sampling method: whole test solution of each vessel was used - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 7 d
- Remarks on result:
- other: average
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 14 d
- Remarks on result:
- other: average
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 21 d
- Remarks on result:
- other: average
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 28 d
- Remarks on result:
- other: average
- Results with reference substance:
- The reference substance aniline was biodegradaded with 70% after 28 days. Furthermore, the 10-day window was fulfilled. Therefore, the test is valid.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The biodegradation of the test substance MTHP was determined according to "Method for Testing the Biodegradability of Chemical Substances by Microorganisms" stipulated in the "Testing Methods for New Chemical Substances" (Japan) and in compliance with GLP. The biodegradation of MTHP was determined to be on average 2% based on the biochemical oxygen demand. MTHP is, therefore, not readily biodegradable according to OECD criteria.
Reference
Table 1: Percentage biodegradation of MTHP based on biochemical oxygen demand (BOD)
|
7 days |
14 days |
21 days |
28 days |
|
||||
Vessel No. |
BOD (mg) |
Deg. (%) |
BOD (mg) |
Deg. (%) |
BOD (mg) |
Deg. (%) |
BOD (mg) |
Deg. (%) |
Mean degradation (%) |
1 |
0 |
- |
0.1 |
- |
0.2 |
- |
0.3 |
- |
- |
2 |
4.9 |
2 |
7.7 |
2 |
8.9 |
1 |
9.4 |
1 |
2 |
3 |
4.3 |
1 |
6.8 |
1 |
8.1 |
0 |
8.7 |
0 |
|
4 |
3.5 |
- |
6.2 |
- |
8.1 |
- |
8.4 |
- |
|
5 |
3.5 |
- |
6.2 |
- |
8.1 |
- |
8.4 |
- |
- |
6 |
56.7 |
59 |
67.1 |
67 |
69.4 |
68 |
71.9 |
70 |
66 |
Vessel No. 1: Water + test item
Vessel No. 2, 3 and 4: Sludge + test item
Vessel No. 5: Sludge + water
Vessel No. 6: Sludge + aniline
Description of key information
Not readily biodegradable (biodegradation in water 2% based on BOD within 28 days)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The biodegradation of the test substance MTHP was determined according to "Method for Testing the Biodegradability of Chemical Substances by Microorganisms" stipulated in the "Testing Methods for New Chemical Substances" (Japan) and in compliance with GLP. The biodegradation of MTHP was determined to be on average 2% based on the biochemical oxygen demand. MTHP is, therefore, not readily biodegradable according to OECD criteria.
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