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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 November 2017 - 11 January 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Isophthalohydrazide
EC Number:
220-425-7
EC Name:
Isophthalohydrazide
Cas Number:
2760-98-7
Molecular formula:
C8H10N4O2
IUPAC Name:
isophthalohydrazide
Test material form:
solid: particulate/powder
Details on test material:
Appearance: White crystal powder
Test item storage: At room temperature

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Any other information on results incl. tables

Table 1 : Results of the isothermal TGA analysis

Temperature [°C]

Weight loss [µg/min]

νT

[g/cm2/h]

log νT

log PT

PT[Pa]

200

0.788581

9.41×10-5

-4.03

-0.02

0.96

 

0.838073

1.00×10-4

-4.00

0.02

1.0

210

1.71692

2.05×10-4

-3.69

0.42

2.6

 

1.81594

2.17×10-4

-3.66

0.45

2.8

220

4.74951

5.67×10-4

-3.25

0.98

9.6

 

5.07770

6.06×10-4

-3.22

1.02

10

The calculated vapour pressure of the test substance was outside the validated range of the method (see Table 2)

According to this, the vapour pressure of the test substance was determined to be lower than that of benzo(ghi)perylene.

Table 2: Calculated Vapour Pressure of the Test Item

Temperature [°C]

log PT

  PT[Pa]

20

-15.15

  7.1×10-16

25

-14.48

  3.3×10-15

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C was determined to be < 1.3E-8 Pa.
The vapour pressure of the substance at 25°C was determined to be < 7.2E-8 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 200°C, 210°C and 220°C however The vapour pressure of the substance at 20°C and 25°C, calculated by extrapolation of the curve, were outside the validated range of the method. As the vapour pressure of the test substance was determined to be lower than that of benzo(ghi)perylene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 1.3E-8 Pa and < 7.2E-8 Pa, resp.