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EC number: 220-425-7 | CAS number: 2760-98-7
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 November 2017 - 11 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- Isophthalohydrazide
- EC Number:
- 220-425-7
- EC Name:
- Isophthalohydrazide
- Cas Number:
- 2760-98-7
- Molecular formula:
- C8H10N4O2
- IUPAC Name:
- isophthalohydrazide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Appearance: White crystal powder
Test item storage: At room temperature
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- < 0 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0 Pa
Any other information on results incl. tables
Table 1 : Results of the isothermal TGA analysis
Temperature [°C] |
Weight loss [µg/min] |
νT [g/cm2/h] |
log νT |
log PT |
PT[Pa] |
200 |
0.788581 |
9.41×10-5 |
-4.03 |
-0.02 |
0.96 |
|
0.838073 |
1.00×10-4 |
-4.00 |
0.02 |
1.0 |
210 |
1.71692 |
2.05×10-4 |
-3.69 |
0.42 |
2.6 |
|
1.81594 |
2.17×10-4 |
-3.66 |
0.45 |
2.8 |
220 |
4.74951 |
5.67×10-4 |
-3.25 |
0.98 |
9.6 |
|
5.07770 |
6.06×10-4 |
-3.22 |
1.02 |
10 |
The calculated vapour pressure of the test substance was outside the validated range of the method (see Table 2)
According to this, the vapour pressure of the test substance was determined to be lower than that of benzo(ghi)perylene.
Table 2: Calculated Vapour Pressure of the Test Item
Temperature [°C] |
log PT |
PT[Pa] |
20 |
-15.15 |
7.1×10-16 |
25 |
-14.48 |
3.3×10-15 |
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of the substance at 20°C was determined to be < 1.3E-8 Pa.
The vapour pressure of the substance at 25°C was determined to be < 7.2E-8 Pa. - Executive summary:
The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.
The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 200°C, 210°C and 220°C however The vapour pressure of the substance at 20°C and 25°C, calculated by extrapolation of the curve, were outside the validated range of the method. As the vapour pressure of the test substance was determined to be lower than that of benzo(ghi)perylene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 1.3E-8 Pa and < 7.2E-8 Pa, resp.
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