Isophthalohydrazide

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 November 2017 - 11 January 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

Isophthalohydrazide

EC Number:

220-425-7

EC Name:

Isophthalohydrazide

Cas Number:

2760-98-7

Molecular formula:

C8H10N4O2

IUPAC Name:

isophthalohydrazide

Test material form:

solid: particulate/powder

Details on test material:

Appearance: White crystal powder
Test item storage: At room temperature

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

231 °C

Decomposition:

yes

Remarks on result:

other: Decomposition started during melting.

Any other information on results incl. tables

TGA EXPERIMENT (PRELIMINARY TEST)

Significant decrease of weight from 275°C. 25% weight loss at 362°C and 51% weight loss at 549°C.

After the experiment, a black charred expended residue remained in the sample container (original colour: white) and a black residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item.

DSC EXPERIMENT 1

 An endothermic peak was observed between 200°C and 250°C directly followed by an exothermic effect starting at 275°C. The extrapolated onset temperature of the first peak was 230.980°C. The endothermic effect was most likely obtained due to melting of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item. After the experiment, a yellow expended residue remained in the sample container (original colour: white) and a yellow residue was observed on the lid of the sample container. Based on this visual observation, it was found that the test item had molten and the change of the colour demonstrated reaction and/or decomposition of the test item.

DSC EXPERIMENT 2

In order to investigate the melting peak, Experiment 2 was stopped directly after the melting peak. The extrapolated onset temperature was 230.974°C. After the experiment, a yellow white molten residue remained in the sample container. The change of the colour indicated reaction and/or decomposition of the test item. It demonstrated that melting was the reason for the endothermic effect.

DATA HANDLING

The melting temperature was determined as the mean of the extrapolated onset temperature of Experiment 1 and Experiment 2.

Applicant's summary and conclusion

Conclusions:

The melting temperature of the substance was determined to be 231°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 231°C.

Reaction and/or decomposition of the substance started during melting.