Registration Dossier
Registration Dossier
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EC number: 609-091-7 | CAS number: 35202-54-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- The study was performed in compliance with the following regulations or guidelines:
OECD Guideline for the Testing of Chemicals No. 437 (updated 26 July 2013)
“Bovine Corneal Opacity and Permeability Assay”
Method B.47 of Commission Regulation (EC) No. 440/2008 - Deviations:
- yes
- Remarks:
- When performing the optical density measurements it was obvious from the coloration of the wells that dilutions needed to be formed on the positive controls, so one run was performed to include dilutions. However this is a deviation to the study plan but
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
- EC Number:
- 609-091-7
- Cas Number:
- 35202-54-1
- Molecular formula:
- C11H11NO2
- IUPAC Name:
- 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
Constituent 1
Test animals / tissue source
- Species:
- cattle
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- ca. 0.5
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No category. Not requiring classification to UN GHS or EU CLP.
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