Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 701-237-9 | CAS number: -
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This information was obtained from the public IUCLID 2000 CD-ROM. The original report has not been reviewed further. Assessment of data quality to current OECD standards is not possible and the study has therefore been assigned Reliability 4.
Data source
Reference
- Reference Type:
- publication
- Title:
- The effects of ethylene-1-hydroxy-1,1-diphosphonate on cellular transformation and organic matrix of the epiphyseal growth plate of the rat: a light microscopic and ultrastructural study
- Author:
- Larsson A and Larsson SE
- Year:
- 1 978
- Bibliographic source:
- Acta Pathologica et Microbiologica Scandinavia, SectA Pathology, 86, 211-224
Materials and methods
- Type of study / information:
- Type: other: effects on bone
Test material
- Reference substance name:
- (1-hydroxyethylidene)bisphosphonic acid, sodium salt
- EC Number:
- 249-559-4
- EC Name:
- (1-hydroxyethylidene)bisphosphonic acid, sodium salt
- Molecular formula:
- C2H8O7P2.xNa
- IUPAC Name:
- (1-hydroxyethylidene)bisphosphonic acid, sodium salt
- Test material form:
- not specified
- Details on test material:
- Substance name as cited in the report: HEDP-xNa
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- EHDP, at the doses used tested had a profound inhibitory effect on the differentiation and migration of the epiphyseal chondrocytes as well as on the degradation of proteoglycan macromolecules. The observed inhibition of vascular invasion appears to be related to inhibition of enzymatic degradation of the ground substance, as evidenced by the observation of extracellular lysosomelike bodies in the erosion zones.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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