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EC number: 701-411-4
CAS number: -
mean viability of epidermises treated with the positive control
during 3 minutes is 91.65%, which is not in the range of our
historical data (values between 5.13% and 42.55%).
considering the results obtained after a treatment during 1 hour,
there is no doubt that the test item is not corrosive. Therefore,
it is considered as without impact on the conclusion of the study.
aim of the study was to evaluate the possible
corrosive effects of the test item after topical
reconstituted epidermis (epiCS®,
test item Copper
diethylenetriamine sulfate was
applied as supplied, during 3 minutes and 1
hour, at the dose of 25 mg, to 2 living Human
skin model surfaces (epiCS®,
previously moistened with 25 μL of distilled
water. The application was followed by a rinse
with 20 mL of DPBS. Cell viability was then
measured by enzymatic conversion of the vital
dye MTT into a blue formazan salt that was
quantitatively measured after extraction from
experimental protocol was established in
accordance with theO.E.C.D.
Test Guideline No. 431 dated 28 July 2015 and
the method B.40bis of the Council regulation No.
minutes and 1 hour after the test item
application, the mean percent viability of the
epidermis skins treated with the test item were 97.28
versus 91.65% and 0.31%, respectively, with the
positive control item (potassium hydroxide 8N).
accordance with the Regulation (EC) No.
1272/2008, the results obtained under these
experimental conditions enable to conclude that
the test item Copper
diethylenetriamine sulfate does not have tobe
classified in Category 1 “Corrosive”.
hazard statement “H314: Causes severe skin burns
and eye damage” with the signal word “Danger”
are not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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