Registration Dossier
Registration Dossier
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EC number: 208-235-2 | CAS number: 517-23-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977- no more details available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data available
- GLP compliance:
- not specified
- Test type:
- other: no information available
- Limit test:
- no
Test material
- Reference substance name:
- α-acetyl-γ-butyrolactone
- EC Number:
- 208-235-2
- EC Name:
- α-acetyl-γ-butyrolactone
- Cas Number:
- 517-23-7
- Molecular formula:
- C6H8O3
- IUPAC Name:
- 3-acetyloxolan-2-one
Constituent 1
- Specific details on test material used for the study:
- No data
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- No data
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 500 mg/kg bw
- Remarks on result:
- other: after 10 days
- Sex:
- male/female
- Dose descriptor:
- other: LD10
- Effect level:
- 6 700 mg/kg bw
- Remarks on result:
- other: after 10 days
- Sex:
- male/female
- Dose descriptor:
- other: LD90
- Effect level:
- 10 600 mg/kg bw
- Remarks on result:
- other: after 10 days
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Any other information on results incl. tables
The tests were carried out by using 10 animals per dosage group. The routes of adninistration were oral (by gavage). The lethal doses were determined by the computer method developed by Dr S. Wolf. The LD 10, LD 50, and LD 90 are stated for observation periods of 24 hours and of 10 days. The LD 50 value for A-Lactone was found to be 8500 mg/kg bw (after 10 days).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Substance is not toxic
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