Registration Dossier
Registration Dossier
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EC number: 208-235-2 | CAS number: 517-23-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29.01.-12.02.1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- α-acetyl-γ-butyrolactone
- EC Number:
- 208-235-2
- EC Name:
- α-acetyl-γ-butyrolactone
- Cas Number:
- 517-23-7
- Molecular formula:
- C6H8O3
- IUPAC Name:
- 3-acetyloxolan-2-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 3.25
- Reversibility:
- fully reversible
- Other effects:
- Generally slight diffuse corneal opacity was observed in the animals nos. 67 (male) and 68 (female) from 1 to 48 hours after treatment. Generally slight diffuse corneal opacity was observed in the animal no. 69 (female) at 1 to 72 hours. At day 7 slightly spotted diffuse corneal opacity was observed in the
same animal only.
Any other information on results incl. tables
no other remarks
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Under the conditions of this experiment, A-LACTON was found to cause a primary irritation score of: 3.25, when applied to the conjunctival sac of the rabbit eye.
- Executive summary:
Under the conditions of this experiment, A-LACTON was found to cause a primary irritation score of: 3.25, when applied to the conjunctival sac of the rabbit eye.
Generally slight diffuse corneal opacity was observed in the animals nos. 67 (male) and 68 (female) from 1 to 48 hours after treatment. Generally slight diffuse corneal opacity was observed in the animal no. 69 (female) at 1 to 72 hours. At day 7 slightly spotted diffuse corneal opacity was observed in the same animal only.
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