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EC number: 294-939-5 | CAS number: 91771-47-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cedrus deodara, Pinaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 19 April 2018 - 19 April 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Himalayan Cedarwood oil is an UVCB substance. Regarding the different solubility of its constituents that make the testing difficult and a known fraction of 91.57%, calculation from the ecotoxicity of the known constituent appears as an acceptable approach.
- Principles of method if other than guideline:
- A calculation method prediction was performed to assess the acute toxicity to Daphnia magna of the test item Himalayan Cedarwood oil, a Natural Complex Substance, using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 202, "Daphnia sp., Acute Immobilisation Test" (1), referenced as Method C.2 of Commission Regulation No. 440/2008 (2) adapted for testing of a mixture using the WAF method. The criterion predicted was the median effective loading rate of the mixture EL50 (Median Effect Loading), a statistically derived loading rate which is expected to cause immobility in 50% of test animals within a period of 48 hours.The acute toxicity to the daphnids was determined using a calculation method for the Mechanism of Action (MechoA) in question (MechoA 1, i.e. narcosis) (3). This method has previously been validated in an internal publication for acute exposure of non-polar narcosis compounds (Bicherel and Thomas, 2014) (4). The algorithm is based on a QSAR model which has been validated to be compliant with the OECD recommendations for QSAR modeling (OECD, 2004; OECD, 2007) (5,6. The QSAR model is based on validated data for a training set of 58 chemicals derived from 48-hour test on daphnids, for which the concentrations of the test item had been determined by chemical analyses over the test period. Further to this the effective loading rate of the WAF is determined by using a series of calculation steps using phase equilibrium thermodynamics and excluding the non-bioavailable fraction, this approach is based on validated data derived from 48-hour EL50 tests on daphnid, for which the concentrations of the test item had been determined by chemical analyses over the test period.
(1) OECD Guideline for testing of chemicals No. 202, "Daphnia sp., Acute Immobilisation Test", adopted April 13, 2004.
(2) Commission Regulation (EC) No. 440/2008, Part C, C.2.: "Daphnia sp. Acute Immobilisation Test", p. 456-463, Official Journal of the European Union (EN), dated May 30, 2008, L 142:1-739.
(3) Bauer, F.J., Thomas, P.C., Fouchard, S.Y., and Neunlist, S.J.M. (2018). A new classification algorithm based on mechanisms of action. Comput. Toxicol. 5, 8–15.
(4) Bicherel P and Thomas PC (2014) iSafeRat® WAF calculation method to predict acute aquatic toxicity. Position paper prepared by KREATiS.
(5) OECD (2004) Principles for the validation for regulatory purposes of (Quantitative) Structure Activity-Relationship Models.
(6) OECD (2007) Guidance document on the validation of (Quantitative)Structure-Activity Relationships [(Q)SAR] models. ENV/JM/MONO(2007)2. Environment Directorate OECD. Paris. Mars 2007. - GLP compliance:
- no
- Analytical monitoring:
- no
- Remarks:
- Not required for a calculation based on multiple QSARs method.
- Details on sampling:
- Not relevant
- Test organisms (species):
- Daphnia sp.
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 7.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Calculation based on QSARs
- Remarks:
- the effective loading rate of the WAF is determined by using a series of calculation steps using phase equilibrium thermodynamics and excluding the non-bioavailable fraction
- Validity criteria fulfilled:
- not applicable
- Remarks:
- QSAR model validated to be compliant with the OECD recommendation for QSAR modelling (OECD, 2004) described within the QMRF.
- Conclusions:
- The 48-hour EL50 of Himalayan Cedarwood oil was concluded 7.8 mg/L.
- Executive summary:
A calculation method prediction was performed to assess the acute toxicity to daphnids of the test item Himalayan Cedarwood oil, a Natural Complex Substance, using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 202, "Daphnia sp., Acute Immobilisation Test", referenced as Method C.2 of Commission Regulation No. 440/2008 adapted for testing of a mixture using the WAF method. The test item falls within the applicability domain of the model and was therefore reliably predicted for its acute toxicity (48h-EL50) to daphnids. By using a "known constituents approach" based on non-polar-narcosis MOA-1 QSARs and WAF "adapted water solubilities”, 48-hour EL50 of Himalayan Cedarwood oil was concluded to be 7.8 mg/L.
Reference
Description of key information
A calculation method prediction was performed to assess the acute toxicity to daphnids of the test item Himalayan Cedarwood oil, a Natural Complex Substance, using the WAF method. This calculation method predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following the Guideline for Testing of Chemicals No. 202, "Daphnia sp., Acute Immobilisation Test", referenced as Method C.2 of Commission Regulation No. 440/2008 adapted for testing of a mixture using the WAF method. The test item falls within the applicability domain of the model and was therefore reliably predicted for its acute toxicity (48h-EL50) to daphnids. By using a "known constituents approach" based on non-polar-narcosis MOA-1 QSARs and WAF "adapted water solubilities”, 48-hour EL50 of Himalayan Cedarwood oil was concluded to be 7.8 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 7.8 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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