Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-027-3 | CAS number: 131-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- HRIPT
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: HRIPT acc. Shelanski and Shelanski
- Version / remarks:
- Patch tests were conducted according to the method of Shelanski and Shelanski (Proceedings Of The Toilet Goods Association, Number 19, May, 1953).
- Deviations:
- not specified
- Principles of method if other than guideline:
- Patch tests were conducted on fifty human volunteers according to the method of Shelanski and Shelanski (Proceedings Of The Toilet Goods Association, Number 19, May, 1953).
- GLP compliance:
- no
- Remarks:
- conducted prior to GLP implementation
- Type of study:
- other: human repeated insult patch test
- Justification for non-LLNA method:
- Study was conducted prior to REACH implementation under a different regulatory context, and prior to the adoption of the respective guidelines.
Test material
- Reference substance name:
- 2,2'-dihydroxy-4,4'-dimethoxybenzophenone
- EC Number:
- 205-027-3
- EC Name:
- 2,2'-dihydroxy-4,4'-dimethoxybenzophenone
- Cas Number:
- 131-54-4
- Molecular formula:
- C15H14O5
- IUPAC Name:
- 2-(2-hydroxy-4-methoxybenzoyl)-5-methoxyphenol
- Test material form:
- solid
Constituent 1
In vivo test system
Test animals
- Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: epicutaneous, patch test
- Vehicle:
- not specified
Challenge
- Route:
- other: epicutaneous, patch test
- Vehicle:
- not specified
- No. of animals per dose:
- 50
- Details on study design:
- Patch tests were conducted on fifty human volunteers according to the method of Shelanski and Shelanski (Proceedings Of The Toilet Goods Association, Number 19, May, 1953).
- Positive control substance(s):
- not required
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- The substance is neither a primary irritant nor a sensitizer. It is not a fatiguing agent.
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 50
- Remarks on result:
- other: no more information given
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Group:
- positive control
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- Given information indicates that the study was performed scientifically reasonable, so the results are considered sufficiently reliable to assess the sensitizing potential of the registered substance in humans. The information is not given in a manner which allows classification according to Regulation 1272/2008 in its classic sense. However, the regulation allows to retrieve information on classification also from other sources. As none of the 50 human volunteers was stated to show reactions, it can be reasonably concluded that the substance would also not meet the classification criteria as set out in the regulation, so the substance can be considered non-sensitizing.
- Executive summary:
Patch tests were conducted on fifty human volunteers according to the method of Shelanski and Shelanski (Proceedings Of The Toilet Goods Association, Number 19, May, 1953). The substance, when tested as supplied, is neither a primary irritant nor a sensitizer. It is not a fatiguing agent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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