Registration Dossier
Registration Dossier
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EC number: 479-150-8 | CAS number: 7784-22-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 479-150-8
- EC Name:
- -
- Cas Number:
- 7784-22-7
- Molecular formula:
- AlH6O6P3
- IUPAC Name:
- Phosphinic acid, aluminum salt (3:1)
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Dose volume: 10 ml/kg
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Six rats were used for the test.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: Signs of toxicity related to dose levels: reduced activity on the day of dosing in the first group of 3 female rats. Hunched posture, piloerection and brown staining in the litter tray were noted up to Day 2, complete recovery occurred by Day 3 in th
- Gross pathology:
- Effects on organs: changes in body weight observed in treated animals were not remarkable. No abnormalities were observed at necropsy examination at termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information according to the CLP Regulation Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Aluminium hypophosphite was administered by gavage on a group of female rats at the highest dose of 2000 mg/kg. No deaths occurred; reduced activity was observed on the day of dosing in the first group of 3 female rats. Hunched posture, piloerection and brown staining in the litter tray were noted up to Day 2, nevertheless complete recovery occurred by Day 3 in the second group of 3 female rats.
Conclusion
LD50 > 2000 mg/kg bw
Aluminium hypophosphite is not classified for oral acute toxicity according to the CLP regulation (EC n. 1272/2008).
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