Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 479-150-8 | CAS number: 7784-22-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.821 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Modified dose descriptor starting point:
- other: NAEC
- Value:
- 61.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Inhalation should not be a preferred route for absorption. Original value is NOAEL 35.2 mg/kg bw, subacute toxicity in rat by oral administration. Allometric scaling from rat to human is 4. The result is multiplied by 70 kg considered as the average weight of a human being (bw) and divided by 10m3/person considered as the average volume that is breathed in a 8h exposure. Conclusion [(35.2 mg/Kg / 4)*70 Kg bw]/10 m3/person= 61.6 mg/m3 bw
- AF for dose response relationship:
- 1
- Justification:
- Not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Already considered (4)
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for intraspecies differences:
- 5
- Justification:
- Worker population
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.173 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- other: modified starting point
- Value:
- 352 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Skin absorption can be considered as negligible and never higher 10 % than oral absorption. A starting value of 10x the NOAEL measured in a oral study is considered.
- AF for dose response relationship:
- 1
- Justification:
- Not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- From rat
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for intraspecies differences:
- 5
- Justification:
- Worker population
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Aluminium hypophosphite is not classified regarding human toxicity.
The assessment is done based on repeated dose toxicity studies (NOAEL 28 days rat = 35.2 mg/kg/bw).
The values of DNEL calculated for workers are:
INHALATION ROUTE:
SYSTEMIC EFFECTS:
a) LONG TERM: DNEL= 0.821 mg/m^3 (NAEC= 61.6 mg/m^3 and Overall AF= 75)
b) SHORT TERM: No hazard identified
LOCAL EFFECTS: No hazard identified for LONG AND SHORT TERM
DERMAL ROUTE:
SYSTEMIC EFFECTS:
a) LONG TERM: DNEL = 1.173 mg/kg/bw day (Modified starting point= 352 mg/kg/bw day and Overall AF= 300)
b) SHORT TERM: No hazard identified
LOCAL EFFECTS: No hazard identified FOR LONG AND SHORT TERM
HAZARD FOR EYE: LOCAL EFFECTS: no hazard identified
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.205 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- other: NAEC
- Value:
- 30.8 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Inhalation should not be a preferred route for absorption. Original value is NOAEL 35.2 mg/kg bw, subacute toxicity in rat by oral administration. Allometric scaling from rat to human is 4. The result is multiplied by 70 kg considered as the average weight of a human being (bw) and divided by 20 m3/person considered as the average volume that is breathed by general population. Conclusion [(35.2 mg/kg / 4)*70 kg bw]/20 = 30.8 mg/m3 bw
- AF for dose response relationship:
- 1
- Justification:
- not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Already considered (4)
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for intraspecies differences:
- 10
- Justification:
- General population
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.587 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- other: modified starting point
- Value:
- 352 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Skin absorption can be considered as negligible and never higher 10 % than oral absorption. A starting value of 10x the NOAEL measured in a oral study is considered.
- AF for dose response relationship:
- 1
- Justification:
- not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- from subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- from rat
- AF for other interspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for intraspecies differences:
- 10
- Justification:
- General population
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.058 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 35.2 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- not necessary
- AF for differences in duration of exposure:
- 6
- Justification:
- From subacute to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- from rat
- AF for other interspecies differences:
- 10
- Justification:
- General population
- AF for intraspecies differences:
- 2.5
- Justification:
- Correction for possible differences in the ADME
- AF for the quality of the whole database:
- 1
- Justification:
- Good quality and reliability
- AF for remaining uncertainties:
- 1
- Justification:
- No further uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Aluminium hypophosphite is not classified regarding human toxicity.
The assessment is done based on repeated dose toxicity studies (NOAEL 28 days rat = 35.2 mg/kg/bw).
The values of DNEL calculated for general population are:
INHALATION ROUTE:
SYSTEMIC EFFECTS:
a) LONG TERM: DNEL= 0.205 mg/m^3 (NAEC= 30.8 mg/m^3 and Overall AF= 150)
b) SHORT TERM: No hazard identified
LOCAL EFFECTS: No hazard identified for LONG AND SHORT TERM
DERMAL ROUTE:
SYSTEMIC EFFECTS:
a) LONG TERM: DNEL = 0.587 mg/kg/bw day (Modified starting point= 352 mg/kg/bw day and Overall AF= 600)
b) SHORT TERM: No hazard identified
LOCAL EFFECTS: No hazard identified FOR LONG AND SHORT TERM
ORAL ROUTE:
SYSTEMIC EFFECTS:
a) LONG TERM: DNEL = 0.058 mg/kg/bw day (NOAEL= 35.2 mg/kg/bw day and Overall AF= 600)
b) SHORT TERM: : No hazard identified
HAZARD FOR EYE:LOCAL EFFECTS: no hazard identified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
