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EC number: 246-515-6 | CAS number: 24887-06-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of Dietary Zinc on the Absorption of Orally Administered Zn65
- Author:
- Furchner JE & Richmond CR
- Year:
- 1 962
- Bibliographic source:
- Health Phys. 8:35-40
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Effect of dietary zinc administration as Zinc acetate was evaluated on the absorption of orally administered Zn65 in rats.
- GLP compliance:
- no
Test material
- Reference substance name:
- Zinc chloride
- EC Number:
- 231-592-0
- EC Name:
- Zinc chloride
- Cas Number:
- 7646-85-7
- Molecular formula:
- Cl2Zn
- IUPAC Name:
- zinc dichloride
- Details on test material:
- - Name of test material (as cited in study report): Zinc chloride
- Specific activity (if radiolabelling): 1.2 µC
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 70 d
- Weight at study initiation: 280 g
- Fasting period before study: No
- Diet (e.g. ad libitum): Pulverized purina laboratory chow, ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 2 wk (with normal diet)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on exposure:
- - Powdered Zinc acetate was added to the food (Pulverized purina laboratory chow) to make the concentration of Zinc 58, 117, 175, 293, 410 and 644 ppm and administered to the rats for 28 d.
- After 28 d of the zinc-supplemented dietary regimen, 1.2 µC of Zn62Cl was administered by gastric gavage while the animals were under light ether anaesthesia. - Duration and frequency of treatment / exposure:
- Zinc chloride: Single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Zinc chloride: 1.2 µC
Zinc acetate: 58, 117, 175, 293, 410 and 644 ppm Zinc
- No. of animals per sex per dose / concentration:
- Nine
- Control animals:
- no
- Positive control reference chemical:
- No
- Details on study design:
- - Rationale for animal assignment: Random
- Details on dosing and sampling:
- - Whole-body activity was determined at 30 min and at 1, 2, 4, 7 and 11 d after injection in the Los Alamos Small Animal Counter (LASAC-III)
- Body weight: Recorded periodically - Statistics:
- ANOVA followed by Duncan's test
Results and discussion
- Preliminary studies:
- Not applicable
Main ADME results
- Type:
- absorption
- Results:
- Retention (%) of Zinc from Zn65 in normal dietary zinc (~58 ppm): At Day 1: 20.22 ± 3.30; At Day 2: 14.86 ± 2.44; At Day 4: 12.73 ± 2.17; At Day 7: 10.74 ± 1.90; At Day 11: 9.22 ± 1.70
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Retention (%) of Zinc from Zn65 in normal dietary zinc (~58 ppm):
- At Day 1: 20.22 ± 3.30
- At Day 2: 14.86 ± 2.44
- At Day 4: 12.73 ± 2.17
- At Day 7: 10.74 ± 1.90
- At Day 11: 9.22 ± 1.70 - Details on distribution in tissues:
- Not applicable
- Details on excretion:
- Not applicable
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable
Any other information on results incl. tables
Table 1. Effect of dietary zinc on the retention of orally administered Zn65 in rats
Group No. |
Stable Zinc in diet (ppm) |
Day |
||||
1 |
2 |
4 |
7 |
11 |
||
1 |
58 |
20.22 ± 3.30 |
14.86 ± 2.44 |
12.73 ± 2.17 |
10.74 ± 1.90 |
9.22 ± 1.70 |
2 |
117 |
15.86 ± 3.50 |
10.78 ± 2.28 |
9.04 ± 1.90 |
7.63 ± 1.57 |
6.47 ± 1.28 |
3 |
175 |
16.68 ± 6.00 |
9.52 ± 1.21 |
7.80 ± 1.09 |
6.57 ± 0.88 |
5.56 ± 0.78 |
4 |
293 |
14.26 ± 7.76 |
9.36 ± 6.69 |
7.77 ± 5.67 |
6.44 ± 4.71 |
5.42 ± 3.85 |
5 |
410 |
12.53 ± 3.97 |
5.96 ± 1.64 |
4.73 ± 1.17 |
3.95 ± 0.92 |
3.30 ± 0.79 |
6 |
644 |
13.15 ± 10.98 |
4.69 ± 2.55 |
3.45 ± 1.59 |
2.88 ± 1.23 |
2.32 ± 0.97 |
Study on human subject: Result
- At 10 d post-ingestion, excretion
increased by more than a factor of 3
- Radioassay of fecal samples showed that, after the first ingestion, 11%
of the Zn65 was excreted during the first 4 d post ingestion
and that, after the second ingestion, 44% was excreted during the first
3 d post ingestion.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other:
Retention of Zinc from Zn62Cl in rats fed with normal dietary zinc (~58 ppm) was determined to be 20.22 ± 3.30, 14.86 ± 2.44, 12.73 ± 2.17, 10.74 ± 1.90 and 9.22 ± 1.70 at 1, 2, 4, 7 and 11 d, respectively. Under the test conditions, dietary zinc was determined to be a major factor regulating the retention of Zinc in rats and human subject. - Executive summary:
A study was conducted to evaluate the effect of dietary zinc on the absorption of orally administered Zn65 in rats.
Diet containing Zinc acetate (58, 117, 175, 293, 410 and 644 ppm Zinc) was administered to the rats for 28 d. After 28 d of the initiation of Zinc acetate diet, 1.2 µC of Zn65Cl was administered by gastric gavage and whole-body activity was determined at 30 min and at 1, 2, 4, 7 and 11 d.
Retention of Zinc from Zn65Cl in rats fed with normal dietary zinc (~58 ppm) was determined to be 20.22±3.30, 14.86±2.44, 12.73±2.17, 10.74±1.90 and 9.22±1.70 at 1, 2, 4, 7 and 11 d, respectively. Rats maintained on diets supplemented with Zinc acetate retained less Zn65 than rats on normal diets. Addition of 6-10 times the normal Zinc intake reduced retention by a factor of 3. Data from human subject showed increase in excretion of Zn65 after ingestion of Zinc acetate diet for 30 d.
Under the test conditions, dietary zinc was determined to be a major factor regulating the retention of Zinc in rats and human subject.
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