Registration Dossier
Registration Dossier
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EC number: 256-917-3 | CAS number: 51022-74-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Iotroxic acid
- Year:
- 1 982
- Bibliographic source:
- Gekkan Yakuji (Pharmaceuticals Monthly). Vol. 24, Pg. 695, 1982
Materials and methods
- Principles of method if other than guideline:
- Collection of data, information on materials and methods are not available.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Iotroxic acid
- EC Number:
- 256-917-3
- EC Name:
- Iotroxic acid
- Cas Number:
- 51022-74-3
- Molecular formula:
- C22H18I6N2O9
- IUPAC Name:
- 3-{2-[2-(2-{[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-2,4,6-triiodobenzoic acid
Constituent 1
- Specific details on test material used for the study:
- no data
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 9 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this acute oral toxicity study, the oral LD50 value in rats after treatment with Iotroxic acid is > 9000 mg/kg.
- Executive summary:
In an acute toxicity study, the toxic potential of Iotroxic acid was tested orally on male and female rats. The LD50 of the test substance for rats was found to be greater than 9000 mg/kg bw for both males and females.
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