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Diss Factsheets
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EC number: 214-014-1 | CAS number: 1072-71-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- In vivo study performed prior (1980) to REACH implementation.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1980-09-30 - 1980-10-03 (experimental phase)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Given information allows the conclusion the study was well performed according to adopted guidelines, given data allows also conclusions on classification according to Regulation 1272/2008.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR Section 1500.41
- Version / remarks:
- The method employed in the testing, evaluation and the scoring of the results was similar to that described in Section 1500.41 ― Federal Hazardous Substances Act Regulations ― 16 CFR - P. 124,
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3,4-thiadiazole-2,5-dithiol
- EC Number:
- 214-014-1
- EC Name:
- 1,3,4-thiadiazole-2,5-dithiol
- Cas Number:
- 1072-71-5
- Molecular formula:
- C2H2N2S3
- IUPAC Name:
- 1,3,4-thiadiazole-2,5-dithiol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR Part 3.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact (clipped only)
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g - Duration of treatment / exposure:
- 24h occlusive under Wrap. no wash-off
- Observation period:
- 72h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: A 0.5 g portion of material was applied to an abraded and an intact skin site on the same rabbit.
- Type of wrap if used: Gauze patches were then placed over the treated areas and an impervious material was wrapped snugly around the trunks of the animals to hold the patches in place.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none washing stated
OBSERVATION TIME POINTS
after 24 and 72 hours
SCORING SYSTEM:
- Method of calculation: The Draize method of scoring was employed. Scoring of the results was similar to that described in Section 1500.41 ― Federal Hazardous Substances Act Regulations ― 16 CFR - P. 124.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24&72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24&72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24&72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Remarks:
- Information on the 48h timepoint not given, but as after 24h and 72h the score in each animal is zero, it can be concluded that this is the case also after 48h.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Remarks:
- Information on the 48h timepoint not given, but as after 24h and 72h the score in each animal is zero, it can be concluded that this is the case also after 48h.
- Irritant / corrosive response data:
- not irritant
- Other effects:
- - Other adverse local effects: none stated
- Other adverse systemic effects: none stated
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Study was performed scientifically reasonable similar to that described in Section 1500.41 ― Federal Hazardous Substances Act Regulations ― 16 CFR - P. 124 on 1,3,4-Thiadiazole-2,5-dithiole, and is sufficiently documented. Hence, the results can be considered as reliable to assess the irritating potential of 1,3,4-Thiadiazole-2,5-dithiole on intact and abraded rabbit skin. The primary irritation score was 0.00, none of the 6 rabbits showed any sign of irritation. Hence, the substance does not need to be classified as skin irritant acc. Regulation 1272/2008.
- Executive summary:
In a primary dermal irritation study (16 CFR Section 1500.41), six Albino rabbits were dermally exposed to each 0.5 g of unchanged 1,3,4-Thiadiazole-2,5-dithiole for 24 hours to intact and abraded skin, no washing. Animals then were observed for 3 days. Irritation was scored by the method of Draize.
The primary irritation score was 0.00, none of the 6 rabbits showed any sign of irritation. The substance does not need to be classified as skin irritant acc. Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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