1,3,4-thiadiazole-2,5-dithiol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-01-11 - 2017-12-22

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

OECD-Test Guideline 105, Edition dated 27.07.95

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: sponsor

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At ambient temperature
- Stability under test conditions: The test item is hydrolytically stable according to OECD 111 tier 1.

Key result

Water solubility:

25.9 g/L

Conc. based on:

test mat.

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

Remarks on result:

other: information on pH not available

Conclusions:

The GLP study was performed according to OECD TG 105 without any deviations on the substance to be registered itself, the results were so obtained via a scientifically reasonable method. Hence, there is no doubt that the obtained results are reliable: The water solubility was determined to be 25.9 g/L; the substance is very soluble in water.

Executive summary:

The test item 2,5-Dimercapto-1,3,4-thiadiazole (“DMTD”) was tested according to OECD-Guideline 105 with the “Flask Method”.

The criterion of the OECD 105 “If the concentrations measured in at least the two last vessels do not differ by more than 15%, the test is satisfactory. If the results from vessels 1, 2 and 3 show a tendency of increasing values, the whole test should be repeated using longer equilibration times.” is relevant to the saturation curve during the measurement of the water solubility. These criterions are reached by this determination. Therefore the test is valid.

During different runs for determination of the water solubility, the test item formed precipitations in aqueous solution after removing the remaining unsolved parts over several days. These precipitations had two different forms, yellow crystals and white fine particles. The test conditions and the specimen treatment were adapted to avoid these precipitations after the performance of the method given by the OECD 105.

According to the definition of the OECD-Guideline 105 the test item shows a water solubility of 25.9 g/l.

Description of key information

Water solubility: 25.9 g/l at 20°C (flask method, OECD 105, GLP)

Key value for chemical safety assessment

Water solubility:

25.9 g/L

at the temperature of:

20 °C