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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
inspected: September 2015; signature: November 2015
Type of method:
differential scanning calorimetry
Melting / freezing pt.:
-8.8 °C
Atm. press.:
ca. 1 004 hPa
Decomposition:
no
Sublimation:
no
Remarks on result:
other: mean melting point (n=3); measurement under flow of nitrogen

Main study

- Experiment 1: During cooling an exothermic peak (crystallisation) was observed between -40°C and -80°C (results are archived in the raw data). During heating an exothermic followed by an endothermic and exothermic peak was observed between -75°C and -25°C. The effects were most likely obtained due to melting with cold crystallisation. An endothermic peak between -25°C and 25°C was observed. The extrapolated onset temperature of the peak was -8.574°C. The endothermic effect was most likely obtained due to melting of the test item.

- Experiment 2: A duplicate DSC was performed to determine the duplicate melting and boiling temperatures of the test item. A lower cooling rate of -1°C/minute and a higher heating rate of 50°C/minute was used from 25°C with more test item. The endothermic peak extrapolated onset of the melting peak was -8.510°C.

- Experiment 3: Using conditions similar to Experiment 2, the endothermic peak extrapolated onset of the melting peak was -9.260°C.

Applicant assessment indicates: The melting temperature of the test item were determined as the average melting temperature obtained from Experiment 1, Experiment 2 and Experiment 3. The individual results were within ±0.5°C of the mean determination of the all three runs (n=3). The highest temperature thermal event in the melting point determination was mean -8.8 °C. At this temperature the substance is liquid.

Conclusions:
The melting temperature of the test item has been determined to be -8.8 ± 0.5 °C (or 264.4 ± 0.5 K). At this temperature the substance is considered to be liquid.
Executive summary:

The melting temperature was determined using OECD TG 102 and EU Method A.1 with the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. The melting temperature of the test item were determined as the mean melting temperature obtained from three experiments; from which the thermal events for each individual DSC-runs were within ± 0.5°C of the determined mean. The mean melting point was -8.8 ± 0.5 °C (264.4 ± 0.5 K). At this temperature the substance is considered to be liquid.

Description of key information

Mp: -8.8 ± 0.5 °C (264.4 ± 0.5 K) at 1 atmosphere, OECD TG 102 - DSC Method, 2017

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-8.8 °C

Additional information

The melting temperature was determined using OECD TG 102 and EU Method A.1 with the Differential Scanning Calorimetry method under GLP. The guideline defines the melting temperature as: the temperature at which the phase transition from solid to liquid state occurs at atmospheric pressure and this temperature ideally corresponds to the freezing temperature. The melting temperature of the test item were determined as the mean melting temperature obtained from three experiments; from which the thermal events for each individual DSC-runs were within ± 0.5°C of the determined mean. The mean melting point was -8.8 ± 0.5 °C (264.4 ± 0.5 K). At this temperature the substance is considered to be liquid..