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Physical & Chemical properties

Vapour pressure

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-04-09 to 2018-06-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
gas saturation method
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Temp.:
40 °C
Vapour pressure:
0 Pa

Preliminary test: The obtained concentration at 20 mL/min was 5.05 mg/L, at 40 mL/min was 6.03 mg/L and at 60 mL/min was 2.40 mg/L.

Definitive test: The obtained concentration at 20 °C was 5.28 mg/L and at 40 °C was 6.25 mg/L, respectively. The vapour pressure for the test item at 20 °C was determined to be 0.25 mPa (0.00025 Pa) and at 40 °C was 0.31 mPa (0.00031 Pa), respectively.

Table 1. Determination of the vapour pressure at 20 °C

Flow Rate
(mL/min)

Sample Code

Sample Peak Area

Slope

Intercept

Dilution Factor

Conc. Obtained      (mg/L)

Mean Conc. Obtained

(mg/L)

(W) Mass of Evaporated Test Item (g)

40

Sample C1 R1 -Rep1

181027

618518.43

15735.98

20

5.34

5.28

0.000005340

Sample C1 R1 -Rep2

180759

618518.43

15735.98

20

5.34

0.000005340

Sample C1 R2 -Rep1

178589

618518.43

15735.98

20

5.27

0.000005270

Sample C1 R2 -Rep2

178636

618518.43

15735.98

20

5.27

0.000005270

Sample C1 R3 -Rep1

176389

618518.43

15735.98

20

5.19

0.000005190

Sample C1 R3 -Rep2

178771

618518.43

15735.98

20

5.27

0.000005270

Table 2. Determination of the vapour pressure at 40 °C

Flow Rate
(mL/min)

Sample Code

Sample Peak Area

Slope

Intercept

Dilution Factor

Conc. Obtained      (mg/L)

Mean Conc. Obtained

(mg/L)

(W) Mass of Evaporated Test Item (g)

40

Sample C2 R1 -Rep1

211012

618518.43

15735.98

20

6.31

6.25

0.000006310

Sample C2 R1 -Rep2

211239

618518.43

15735.98

20

6.32

0.000006320

Sample C2 R2 -Rep1

208513

618518.43

15735.98

20

6.23

0.000006230

Sample C2 R2 -Rep2

208710

618518.43

15735.98

20

6.24

0.000006240

Sample C2 R3 -Rep1

207084

618518.43

15735.98

20

6.19

0.000006190

Sample C2 R3 -Rep2

207273

618518.43

15735.98

20

6.19

0.000006190

Conclusions:
The vapour pressure of the test item was determined to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined using the gas saturation method. A preliminary test with three different nitrogen flow rates (20, 40 and 60 mL/min) at 40 °C was performed. As no significant change in the concentration at the different flow rates was observed, 40 mL/min was selected as a flow rate for the definitive test. Three samples at 20 °C and three samples at 40 °C were maintained at the test temperature for 6 days. At the end of the test the trapping agent was collected and the test item was extracted with 5 mL diluent. The extract was measured with HPLC-UV to determine the test items concentration. The obtained concentration in the definitive test was 5.28 mg/L at 20 °C and 6.25 mg/L at 40 °C, respectively. The vapour pressure was calculated to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C.

Description of key information

The vapour pressure of the test item was determined to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined using the gas saturation method. A preliminary test with three different nitrogen flow rates (20, 40 and 60 mL/min) at 40 °C was performed. As no significant change in the concentration at the different flow rates was observed, 40 mL/min was selected as a flow rate for the definitive test. Three samples at 20 °C and three samples at 40 °C were maintained at the test temperature for 6 days. At the end of the test the trapping agent was collected and the test item was extracted with 5 mL diluent. The extract was measured with HPLC-UV to determine the test items concentration. The obtained concentration in the definitive test was 5.28 mg/L at 20 °C and 6.25 mg/L at 40 °C, respectively. The vapour pressure was calculated to be 0.25 mPa (0.00025 Pa) at 20 °C and 0.31 mPa (0.00031 Pa) at 40 °C.