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EC number: 288-098-3
CAS number: 85650-88-0
The study was designed to assess the acute
oral toxicity of the test material in the rat. The study was designed to
comply with the recommendations of the OECD Guidelines for Testing of
Chemicals (1981) No. 401 "Acute 0ral Toxicity". The test system was
chosen because the rat has been shown to be a suitable model for this
type of study and is recommended in the test method. The results of the
study are believed to be of value in predicting the likely toxicity of
the test material to man. Five male and female Sprague-Dawly rats were
orally administered the pure test item via gavage. Observations one and
four hours after treatment revealed clinical signs of hunched posture
and piloerection. These signs were reversible within one day. No
mortality was observed within the 14 days observation period. No gross
pathological findings were observed in the treated animals. Based on the
results of this study, the LD50 of the test item is considered to be
greater than 5000 mg/kg bw in the rat.
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