Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 January 2018 - 09 February 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Physical appearance: colourless to pale yellow liquid
Storage conditions: at room temperature protected from light, container flushed with nitrogen.
Specific details on test material used for the study:
Boiling point: 299.5°C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
0.093 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0.18 Pa

Any other information on results incl. tables

Table: Results of the isothermal TGA analysis (test item)

Experiment

Temperature [°C]

Weight loss [µg/min]

νT

[g/cm2/h]

log νT

log PT

PT[Pa]

1

50

2.14293

2.56×10-4

-3.59

0.54

3.5

 

60

4.63588

5.53×10-4

-3.26

0.97

9.3

 

70

10.0333

1.20×10-3

-2.92

1.40

25

 

80

20.4364

2.44×10-3

-2.61

1.79

62

2(A)

50

2.84939

3.40×10-4

-3.47

0.70

5.0

 

60

6.50791

7.77×10-4

-3.11

1.16

14

 

70

13.9073

1.66×10-3

-2.78

1.58

38

 

80

26.3093

3.14×10-3

-2.50

1.93

86

3

50

1.94490

2.32×10-4

-3.63

0.49

3.1

 

60

4.52923

5.41×10-4

-3.27

0.96

9.0

 

70

9.88036

1.18×10-3

-2.93

1.39

24

 

80

20.2649

2.42×10-3

-2.62

1.79

61

(A) Experiment 2 was not used in the calculation as Experiment 1 and Experiment 2 had a coefficient of correlation of < 0.99. Since the coefficient of correlation was >0.99 for Experiment 1 and Experiment 3, the results from Experiment 2 were excluded.

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C was determined to be 0.093 Pa.
The vapour pressure of the substance at 25°C was determined to be 0.18 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 50°C, 60°C, 70°C and 80°C. The vapour pressure of the substance at 20°C and 25°C was determined by extrapolation to be 0.093 Pa and 0.18 Pa, resp.