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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 - 21 Jul 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. certificate)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildesheim, Germany
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
119 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.6

Check of the temperature

Temperature at Pre-Incubation (30 °C) and Thermostatisation Phase (20 °C) (measured hourly)

Intended temperature

[°C]

Measured temperature.

[°C]

 

min.

max.

Mean value ± SD

30.0 ± 0.5

29.96

30.08

30.01 ± 0.03

20.0 ± 0.5

19.96

20.02

19.99 ± 0.01

 

 

Check of the pH-Value

The pH-values were determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.

Test

temperature

[°C]

Pre-incubation

time

[h]

Replicate

Measured

pH

Mean

value

20

24

1

6.412

6.6

2

6.398

48

1

6.888

2

6.579

72

1

7.008

2

6.589

Control

7.616

-

 

Check of the Tyndall-Effect

No Tyndall-Effect was observed in any of the test vessels

 

Water Solubility Results

No significant signals were obtained for the control sample.

 

The water solubility results at 20 °C for the test item are reported in the following table.

Preincubation time

Replicate

No.

Concentration (1)

[mg/L]

Mean

[mg/L]

24 h

1

112

115

2

117

48 h

1

118

120

2

122

72 h

1

124

123

2

123

Mean (24 - 72 h)

 

 

119

Deviation [%] (24 - 72 h)

 

 

7.5

(1) Dilution factor of 1000 and exact weight of the standard taken into account

 

Conclusion

The solubility of the test item was determined at 20 ± 0.5 °C to be 119 mg/L (pH 6.6).

Conclusions:
A water solubility value of 119 mg/L (at 20 °C, pH = 6.6) was determined for the test substance according to OECD 105.
Executive summary:

The water solubility of test item was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The Study was performed under GLP. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C and the concentrations were verified by GC-MS. The solubility was measured to be 119 mg/L at 20 °C, pH = 6.6.

Description of key information

Water solubility:  119 mg/L at 20 °C, pH = 6.6 (OECD 105, flask method)

Key value for chemical safety assessment

Water solubility:
119 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of test item was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The Study was performed under GLP. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C and the concentrations were verified by GC-MS. The solubility was measured to be 119 mg/L at 20 °C, pH = 6.6.