Registration Dossier
Registration Dossier
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EC number: 200-824-2 | CAS number: 74-95-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- SIDS INITIAL ASSESSMENT PROFILE
- Author:
- UNEP PUBLICATION
- Year:
- 2 013
- Bibliographic source:
- CoCAM 5, 15- 17 October 2013
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- traditional method
Test material
- Reference substance name:
- Dibromomethane
- EC Number:
- 200-824-2
- EC Name:
- Dibromomethane
- Cas Number:
- 74-95-3
- Molecular formula:
- CH2Br2
- IUPAC Name:
- dibromomethane
1
Test animals
- Species:
- rat
- Strain:
- other: CD albino
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 21.4- 22.3 mg/m3
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 22.3 other: mg/m3
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no mortality
- Other findings:
- no toxicologically relevant changes were noted on autopsy at 18 and 20 days post treatment.
Any other information on results incl. tables
Immediately after exposure excessive fluid excretion was observed, accompanied by impaired spontaneous motor activity as exhibited by slow breathing, uncoordinated and atactic walk, continuous tremor, and excessive preening. All these effects wore off within about 3 hours when most of the exposed animals were found in deep sleep.
Applicant's summary and conclusion
- Conclusions:
- LC50was> 22.3 mg/m3
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