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EC number: 203-626-4 | CAS number: 108-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation (in vivo): Key study. Pyridine was tested by the U.S. National Institute of Environmental Health Sciences in their validation studies of the murine Local Lymph Node Assay (LLNA). Few details are available on the doses or methods used. The EC50 of pyridine in the LLNA is greater than 3; however, this is unexpected as pyridine was a very weak allergen in the human predictive test. Based on read across from the analogue pyridine, 4-methylpyridine could be considered as skin sensitiser according to the test result.
Three members of the category of pyridines, pyridine, 2-methylpyridine and 4-methylpyridine are listed in annex VI of Regulation (EC) No. 1272/2008 (harmonized classification) and none of these are classified as sensitisers.
Thus, 4-methylpyridine should not be considered as skin sensitiser according to CLP Regulation (EC) No 1272/2008 despite of the conclusion obtained in the test with pyridine.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue substance pyridine which shares the same functional groups with the substance 4-methylpyridine also has comparable values for the relevant molecular properties.
See attached the reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- SI
- Value:
- > 3
- Test group / Remarks:
- Test group 1
- Key result
- Parameter:
- SI
- Value:
- > 3
- Test group / Remarks:
- Test group 2
- Key result
- Parameter:
- SI
- Value:
- > 3
- Test group / Remarks:
- Test group 3
- Key result
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: no data
- Interpretation of results:
- other: ambiguous
- Conclusions:
- The EC50 of pyridine in the LLNA is greater than 3; however, this is unexpected as pyridine was a very weak allergen in the human predictive test. Based on read across from the analogue pyridine, the substance should not be regarded as skin sensitiser despite the conclusion obtained in the test.
- Executive summary:
Pyridine was tested by the U.S. National Institute of Environmental Health Sciences in their validation studies of the murine Local Lymph Node Assay (LLNA). Few details are available on the doses or methods used. The EC50 of pyridine in the LLNA is greater than 3; however, this is unexpected as pyridine was a very weak allergen in the human predictive test. Based on these results, the read-across approach was applied and despite the conclusion obtained the substance should not be regarded as skin sensitiser.
Reference
Pyridine is a very weak allergen in the human predictive test and so the conclusion that pyridine is positive in the LLNA was unexpected. The conclusion that pyridine is a sensitiser is not clear.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, the substance is not classified for skin sensitization according to CLP Regulation no. 1272/2008.
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